Abstract
The influence of nanoparticle (NP) formulations on the pharmacokinetic, pharmacodynamic and biodistribution profiles of peptide- and protein-like drugs following oral administration is critically reviewed. The possible mechanisms of absorption enhancement and the effects of the physicochemical properties of the NP are examined. The potential advantages and challenges of physiologically-based pharmacokinetic (PBPK) modelling to help predict efficacy in man are discussed. The importance of developing and expanding the regulatory framework to help translate the technology into the clinic and accelerate the availability of oral nanoparticulate formulations is emphasized. In conclusion, opportunities for future work to improve the state of the art of oral nanomedicines are identified.
| Original language | English |
|---|---|
| Pages (from-to) | 367-380 |
| Number of pages | 14 |
| Journal | Advanced Drug Delivery Reviews |
| Volume | 106 |
| DOIs | |
| Publication status | Published - 15 Nov 2016 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Bioavailability
- Nanoparticles for oral administration
- Pharmacokinetics and pharmacodynamics of peptide and protein drugs
- Physiologically-based pharmacokinetic modelling
- Regulatory challenges
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