Pharmacokinetic studies of δ amino levulinic acid-induced protoporphyrin IX build-up in some malignant tumours

Katarina Svanberg; Laudelina Pais Clemente; Manuel Pais Clemen; Ingrid Wang; Trond Warloe; Stefan Andersson-Engels; Roger Berg; Johan Moan; Qian Peng; Sune Svanberg

doi:10.1117/12.206834

Pharmacokinetic studies of δ amino levulinic acid-induced protoporphyrin IX build-up in some malignant tumours

Katarina Svanberg
, Laudelina Pais Clemente
, Manuel Pais Clemen
, Ingrid Wang
, Trond Warloe
, Stefan Andersson-Engels
, Roger Berg
, Johan Moan
, Qian Peng
, Sune Svanberg

Research output: Contribution to journal › Article › peer-review

Abstract

Laser4nduced fluorescence was used for the monitoring of the &-amino levulinic acid (ALA)-induced protoporphyrin IX (PpIX) build-up in non-melanoma malignant tumours of the skin and some cancers in the head and neck region. An optical-fibre based point monitoring system was utilised in the recording of fluorescence spectra at different time intervals after the administration of ALA. In the cases of skin tumours ALA was normally applied topically to the area. Only in one patient with an aggressive skin tumour ALA was administered intravenously. For the PpIX induction in the head and neck tumours the ALA was given orally. An example ofa tumour fluorescence image is also presented.

Original language	English
Pages (from-to)	30-42
Number of pages	13
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	2387
DOIs	https://doi.org/10.1117/12.206834
Publication status	Published - 12 Apr 1995
Externally published	Yes
Event	Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II 1995 - San Jose, United States Duration: 1 Feb 1995 → 28 Feb 1995

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10.1117/12.206834

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Svanberg, K., Clemente, L. P., Clemen, M. P., Wang, I., Warloe, T., Andersson-Engels, S., Berg, R., Moan, J., Peng, Q., & Svanberg, S. (1995). Pharmacokinetic studies of δ amino levulinic acid-induced protoporphyrin IX build-up in some malignant tumours. Proceedings of SPIE - The International Society for Optical Engineering, 2387, 30-42. https://doi.org/10.1117/12.206834

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title = "Pharmacokinetic studies of δ amino levulinic acid-induced protoporphyrin IX build-up in some malignant tumours",

abstract = "Laser4nduced fluorescence was used for the monitoring of the \&-amino levulinic acid (ALA)-induced protoporphyrin IX (PpIX) build-up in non-melanoma malignant tumours of the skin and some cancers in the head and neck region. An optical-fibre based point monitoring system was utilised in the recording of fluorescence spectra at different time intervals after the administration of ALA. In the cases of skin tumours ALA was normally applied topically to the area. Only in one patient with an aggressive skin tumour ALA was administered intravenously. For the PpIX induction in the head and neck tumours the ALA was given orally. An example ofa tumour fluorescence image is also presented.",

author = "Katarina Svanberg and Clemente, \{Laudelina Pais\} and Clemen, \{Manuel Pais\} and Ingrid Wang and Trond Warloe and Stefan Andersson-Engels and Roger Berg and Johan Moan and Qian Peng and Sune Svanberg",

note = "Publisher Copyright: {\textcopyright} 1995 SPIE. All rights reserved.; Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II 1995 ; Conference date: 01-02-1995 Through 28-02-1995",

year = "1995",

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doi = "10.1117/12.206834",

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T1 - Pharmacokinetic studies of δ amino levulinic acid-induced protoporphyrin IX build-up in some malignant tumours

AU - Svanberg, Katarina

AU - Clemente, Laudelina Pais

AU - Clemen, Manuel Pais

AU - Wang, Ingrid

AU - Warloe, Trond

AU - Andersson-Engels, Stefan

AU - Berg, Roger

AU - Moan, Johan

AU - Peng, Qian

AU - Svanberg, Sune

PY - 1995/4/12

Y1 - 1995/4/12

N2 - Laser4nduced fluorescence was used for the monitoring of the &-amino levulinic acid (ALA)-induced protoporphyrin IX (PpIX) build-up in non-melanoma malignant tumours of the skin and some cancers in the head and neck region. An optical-fibre based point monitoring system was utilised in the recording of fluorescence spectra at different time intervals after the administration of ALA. In the cases of skin tumours ALA was normally applied topically to the area. Only in one patient with an aggressive skin tumour ALA was administered intravenously. For the PpIX induction in the head and neck tumours the ALA was given orally. An example ofa tumour fluorescence image is also presented.

AB - Laser4nduced fluorescence was used for the monitoring of the &-amino levulinic acid (ALA)-induced protoporphyrin IX (PpIX) build-up in non-melanoma malignant tumours of the skin and some cancers in the head and neck region. An optical-fibre based point monitoring system was utilised in the recording of fluorescence spectra at different time intervals after the administration of ALA. In the cases of skin tumours ALA was normally applied topically to the area. Only in one patient with an aggressive skin tumour ALA was administered intravenously. For the PpIX induction in the head and neck tumours the ALA was given orally. An example ofa tumour fluorescence image is also presented.

UR - https://www.scopus.com/pages/publications/0011479920

U2 - 10.1117/12.206834

DO - 10.1117/12.206834

M3 - Article

AN - SCOPUS:0011479920

SN - 0277-786X

VL - 2387

SP - 30

EP - 42

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II 1995

Y2 - 1 February 1995 through 28 February 1995

ER -

Pharmacokinetic studies of δ amino levulinic acid-induced protoporphyrin IX build-up in some malignant tumours

Abstract

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