@inproceedings{8202a0c63055406fb94230d0e8b199a5,
title = "Pharmacokinetic study of a systemically administered novel liposomal Temoporfin formulation in an animal tumor model",
abstract = "Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (international generic name Temoporfin) is a potent photosensitizer used for photodynamic therapy (PDT). In this study the pharmacokinetics of a systemically administered novel lipid formulation of Temoporfin in a murine tumor model has been investigated. Fluorescence spectroscopy measurements were performed at several time intervals following drug administration, yielding information on the Temoporfin concentration within excised internal organs as a function of time after injection. Both point-monitoring and imaging setups were used. The acquired fluorescence data were correlated to the concentration of Temoporfin obtained with High Performance Liquid Chromatography (HPLC). There was a significant correlation between the fluorescence methods and HPLC for most organs investigated. The pharmacokinetics of this new liposomal formulation of Temoporfin exhibited a rather flat temporal profile in the time interval 2-8 hours in this study.",
keywords = "Fluorescence spectroscopy, Pharmacokinetics, Temoporfin",
author = "Jenny Svensson and Ann Johansson and Niels Bendsoe and Susanna Gr{\"a}fe and Tilmann Trebst and Stefan Andersson-Engels and Katarina Svanberg",
year = "2007",
doi = "10.1117/12.698932",
language = "English",
isbn = "0819465402",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optical Methods for Tumor Treatment and Detection",
note = "Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI ; Conference date: 20-01-2007 Through 21-01-2007",
}