Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production

Edward C. Deehan; Chen Yang; Maria Elisa Perez-Muñoz; Nguyen K. Nguyen; Christopher C. Cheng; Lucila Triador; Zhengxiao Zhang; Jeffrey A. Bakal; Jens Walter

doi:10.1016/j.chom.2020.01.006

Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production

Edward C. Deehan
, Chen Yang
, Maria Elisa Perez-Muñoz
, Nguyen K. Nguyen
, Christopher C. Cheng
, Lucila Triador
, Zhengxiao Zhang
, Jeffrey A. Bakal
, Jens Walter

University of Alberta

Research output: Contribution to journal › Article › peer-review

Abstract

Deehan et al. show that chemically modified resistant starches with small structural differences induce divergent and highly specific effects on the gut microbiome that direct changes in the output of either propionate or butyrate. Dominant effects were remarkably consistent within treatment groups and dose-dependent with a plateau at 35 g.

Original language	English
Pages (from-to)	389-404.e6
Journal	Cell Host and Microbe
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2020.01.006
Publication status	Published - 11 Mar 2020

Keywords

butyrate
dietary fiber
dose-response
gut microbiome
prebiotic
precision microbiome modulation
propionate
resistant starch
short-chain fatty acids

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10.1016/j.chom.2020.01.006

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title = "Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production",

abstract = "Deehan et al. show that chemically modified resistant starches with small structural differences induce divergent and highly specific effects on the gut microbiome that direct changes in the output of either propionate or butyrate. Dominant effects were remarkably consistent within treatment groups and dose-dependent with a plateau at 35 g.",

keywords = "butyrate, dietary fiber, dose-response, gut microbiome, prebiotic, precision microbiome modulation, propionate, resistant starch, short-chain fatty acids",

author = "Deehan, \{Edward C.\} and Chen Yang and Perez-Mu{\~n}oz, \{Maria Elisa\} and Nguyen, \{Nguyen K.\} and Cheng, \{Christopher C.\} and Lucila Triador and Zhengxiao Zhang and Bakal, \{Jeffrey A.\} and Jens Walter",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = mar,

day = "11",

doi = "10.1016/j.chom.2020.01.006",

language = "English",

volume = "27",

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TY - JOUR

T1 - Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production

AU - Deehan, Edward C.

AU - Yang, Chen

AU - Perez-Muñoz, Maria Elisa

AU - Nguyen, Nguyen K.

AU - Cheng, Christopher C.

AU - Triador, Lucila

AU - Zhang, Zhengxiao

AU - Bakal, Jeffrey A.

AU - Walter, Jens

PY - 2020/3/11

Y1 - 2020/3/11

N2 - Deehan et al. show that chemically modified resistant starches with small structural differences induce divergent and highly specific effects on the gut microbiome that direct changes in the output of either propionate or butyrate. Dominant effects were remarkably consistent within treatment groups and dose-dependent with a plateau at 35 g.

AB - Deehan et al. show that chemically modified resistant starches with small structural differences induce divergent and highly specific effects on the gut microbiome that direct changes in the output of either propionate or butyrate. Dominant effects were remarkably consistent within treatment groups and dose-dependent with a plateau at 35 g.

KW - butyrate

KW - dietary fiber

KW - dose-response

KW - gut microbiome

KW - prebiotic

KW - precision microbiome modulation

KW - propionate

KW - resistant starch

KW - short-chain fatty acids

UR - https://www.scopus.com/pages/publications/85081025727

U2 - 10.1016/j.chom.2020.01.006

DO - 10.1016/j.chom.2020.01.006

M3 - Article

C2 - 32004499

AN - SCOPUS:85081025727

SN - 1931-3128

VL - 27

SP - 389-404.e6

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 3

ER -

Precision Microbiome Modulation with Discrete Dietary Fiber Structures Directs Short-Chain Fatty Acid Production

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Keywords

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