Predicting 5-year-olds mental health at birth: Development and internal validation of a multivariable model using the prospective ELFE birth cohort

We developed and internally validated a multivariable model to be used in the perinatal period, to predict 5-year-olds mental health, using the ELFE prospective French multicentre birth cohort (n=9768). Twenty-six candidate predictors were used, spanning pre-pregnancy maternal health, pregnancy-specific-experiences, birth factors and sociodemographic risk (maternal age, education, relationship, migrancy and family income). The Strengths and Difficulties Questionnaire total score at 5-years, dichotomised at the recommended cut-off (16), was the outcome. Least Absolute Shrinkage and Selector Operator followed by bootstrapping was used. High and low-risk was classified by ≥8% risk-threshold score. Stability of the model at population- and individual-level and model performance across groups of interest (sex, sociodemographic risk and neonatal intensive care admissions) was also examined. 10 variables (total number pregnancy-specific experiences, sociodemographic risk, maternal pre-existing hypertension and psychological difficulties, gravidity, maternal mental health problems in a previous pregnancy, smoking and alcohol use in current pregnancy, how labour started and infant sex) with a C-statistic of 0.67; 95%CI (0.64-0.69) predicted mental health. The positive and negative predictive value were 12% & 95.4% respectively, leading to 78.8% of children correctly classified. Model performance was similar across groups of interest but increased for children (born ≥33-weeks-gestation) with neonatal admissions (AUC 0.78; 95%CI (0.69-0.87)). This model is most useful for identifying low-risk children. Applying this model in a tiered preventative intervention framework could be beneficial with those predicted to be high-risk receiving further screening to determine the level of intervention required. External validation and implementation research are required before considering its use in practice.