Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

John A. Hayes; Kevin S. Eccles; Simon E. Lawrence; Humphrey A. Moynihan

doi:10.1016/j.carres.2011.12.018

Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.

Original language	English
Pages (from-to)	108-112
Number of pages	5
Journal	Carbohydrate Research
Volume	349
DOIs	https://doi.org/10.1016/j.carres.2011.12.018
Publication status	Published - 15 Feb 2012

Keywords

Hydrates
Paracetamol-O-glucuronide
Solvates
X-ray diffraction

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10.1016/j.carres.2011.12.018

https://hdl.handle.net/10468/1018Licence: CC BY-NC-ND

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abstract = "The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.",

keywords = "Hydrates, Paracetamol-O-glucuronide, Solvates, X-ray diffraction",

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AU - Lawrence, Simon E.

AU - Moynihan, Humphrey A.

PY - 2012/2/15

Y1 - 2012/2/15

N2 - The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.

AB - The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.

KW - Hydrates

KW - Paracetamol-O-glucuronide

KW - Solvates

KW - X-ray diffraction

UR - https://www.scopus.com/pages/publications/84856257774

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DO - 10.1016/j.carres.2011.12.018

M3 - Article

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AN - SCOPUS:84856257774

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SP - 108

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JO - Carbohydrate Research

JF - Carbohydrate Research

ER -

Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

Abstract

Keywords

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