Preparation of anti‐1,3‐amino alcohol derivatives through an asymmetric aldol‐tishchenko reaction of sulfinimines

Procedures yielding (S)‐2‐Methyl‐N‐(1‐phenylethylidene)propane‐2‐sulfinamide 3 as two fractions of a yellow solid and (1S,3S)‐1‐(((S)‐tert‐butylsulfinyl)amino)‐4‐methyl‐1‐phenylpentan‐3‐yl isobutyrate as a pale yellow oil are presented. A discussion on 1,3‐aminoalcohols as useful synthetic intermediates and building blocks concludes the chapter.