Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process

Catalina Vallejo-Giraldo; Niccolò Paolo Pampaloni; Anuradha R. Pallipurath; Parvaneh Mokarian-Tabari; John O'Connell; Justin D. Holmes; Alexandre Trotier; Katarzyna Krukiewicz; Gemma Orpella-Aceret; Eugenia Pugliese; Laura Ballerini; Michelle Kilcoyne; Eilís Dowd; Leo R. Quinlan; Abhay Pandit; Paul Kavanagh; Manus Jonathan Paul Biggs

doi:10.1002/adfm.201605035

Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process

Catalina Vallejo-Giraldo
, Niccolò Paolo Pampaloni
, Anuradha R. Pallipurath
, Parvaneh Mokarian-Tabari
, John O'Connell
, Justin D. Holmes
, Alexandre Trotier
, Katarzyna Krukiewicz
, Gemma Orpella-Aceret
, Eugenia Pugliese
, Laura Ballerini
, Michelle Kilcoyne
, Eilís Dowd
, Leo R. Quinlan
, Abhay Pandit
, Paul Kavanagh
, Manus Jonathan Paul Biggs

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Physicochemical modification of implantable electrode systems is recognized as a viable strategy to enhance tissue/electrode integration and electrode performance in situ. In this work, a bench-top electrochemical process to formulate anodized indium tin oxide (ITO) films with altered roughness, conducting profiles, and thickness is explored. In addition, the influence of these anodized films on neural cell adhesion, proliferation, and function indicates that anodized ITO film cytocompatibility can be altered by varying the anodization current density. Furthermore, ITO-anodized films formed with a current density of 0.4 mA cm⁻² show important primary neural cell survival, modulation of glial scar formation, and promotion of neural network activity.

Original language	English
Article number	1605035
Journal	Advanced Functional Materials
Volume	28
Issue number	12
DOIs	https://doi.org/10.1002/adfm.201605035
Publication status	Published - 21 Mar 2018

Keywords

cytocompatibility
electrodes
functionalization
indium tin oxide
neural interfaces

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10.1002/adfm.201605035

https://hdl.handle.net/10468/6516Licence: CC BY-NC-ND

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Vallejo-Giraldo, C., Pampaloni, N. P., Pallipurath, A. R., Mokarian-Tabari, P., O'Connell, J., Holmes, J. D., Trotier, A., Krukiewicz, K., Orpella-Aceret, G., Pugliese, E., Ballerini, L., Kilcoyne, M., Dowd, E., Quinlan, L. R., Pandit, A., Kavanagh, P., & Biggs, M. J. P. (2018). Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process. Advanced Functional Materials, 28(12), Article 1605035. https://doi.org/10.1002/adfm.201605035

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title = "Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process",

abstract = "Physicochemical modification of implantable electrode systems is recognized as a viable strategy to enhance tissue/electrode integration and electrode performance in situ. In this work, a bench-top electrochemical process to formulate anodized indium tin oxide (ITO) films with altered roughness, conducting profiles, and thickness is explored. In addition, the influence of these anodized films on neural cell adhesion, proliferation, and function indicates that anodized ITO film cytocompatibility can be altered by varying the anodization current density. Furthermore, ITO-anodized films formed with a current density of 0.4 mA cm−2 show important primary neural cell survival, modulation of glial scar formation, and promotion of neural network activity.",

keywords = "cytocompatibility, electrodes, functionalization, indium tin oxide, neural interfaces",

author = "Catalina Vallejo-Giraldo and Pampaloni, \{Niccol{\`o} Paolo\} and Pallipurath, \{Anuradha R.\} and Parvaneh Mokarian-Tabari and John O'Connell and Holmes, \{Justin D.\} and Alexandre Trotier and Katarzyna Krukiewicz and Gemma Orpella-Aceret and Eugenia Pugliese and Laura Ballerini and Michelle Kilcoyne and Eil{\'i}s Dowd and Quinlan, \{Leo R.\} and Abhay Pandit and Paul Kavanagh and Biggs, \{Manus Jonathan Paul\}",

note = "Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2018",

month = mar,

day = "21",

doi = "10.1002/adfm.201605035",

language = "English",

volume = "28",

journal = "Advanced Functional Materials",

issn = "1616-301X",

publisher = "John Wiley and Sons Inc",

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Vallejo-Giraldo, C, Pampaloni, NP, Pallipurath, AR, Mokarian-Tabari, P, O'Connell, J, Holmes, JD, Trotier, A, Krukiewicz, K, Orpella-Aceret, G, Pugliese, E, Ballerini, L, Kilcoyne, M, Dowd, E, Quinlan, LR, Pandit, A, Kavanagh, P & Biggs, MJP 2018, 'Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process', Advanced Functional Materials, vol. 28, no. 12, 1605035. https://doi.org/10.1002/adfm.201605035

TY - JOUR

T1 - Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process

AU - Vallejo-Giraldo, Catalina

AU - Pampaloni, Niccolò Paolo

AU - Pallipurath, Anuradha R.

AU - Mokarian-Tabari, Parvaneh

AU - O'Connell, John

AU - Holmes, Justin D.

AU - Trotier, Alexandre

AU - Krukiewicz, Katarzyna

AU - Orpella-Aceret, Gemma

AU - Pugliese, Eugenia

AU - Ballerini, Laura

AU - Kilcoyne, Michelle

AU - Dowd, Eilís

AU - Quinlan, Leo R.

AU - Pandit, Abhay

AU - Kavanagh, Paul

AU - Biggs, Manus Jonathan Paul

PY - 2018/3/21

Y1 - 2018/3/21

N2 - Physicochemical modification of implantable electrode systems is recognized as a viable strategy to enhance tissue/electrode integration and electrode performance in situ. In this work, a bench-top electrochemical process to formulate anodized indium tin oxide (ITO) films with altered roughness, conducting profiles, and thickness is explored. In addition, the influence of these anodized films on neural cell adhesion, proliferation, and function indicates that anodized ITO film cytocompatibility can be altered by varying the anodization current density. Furthermore, ITO-anodized films formed with a current density of 0.4 mA cm−2 show important primary neural cell survival, modulation of glial scar formation, and promotion of neural network activity.

AB - Physicochemical modification of implantable electrode systems is recognized as a viable strategy to enhance tissue/electrode integration and electrode performance in situ. In this work, a bench-top electrochemical process to formulate anodized indium tin oxide (ITO) films with altered roughness, conducting profiles, and thickness is explored. In addition, the influence of these anodized films on neural cell adhesion, proliferation, and function indicates that anodized ITO film cytocompatibility can be altered by varying the anodization current density. Furthermore, ITO-anodized films formed with a current density of 0.4 mA cm−2 show important primary neural cell survival, modulation of glial scar formation, and promotion of neural network activity.

KW - cytocompatibility

KW - electrodes

KW - functionalization

KW - indium tin oxide

KW - neural interfaces

UR - https://www.scopus.com/pages/publications/85016082366

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DO - 10.1002/adfm.201605035

M3 - Article

AN - SCOPUS:85016082366

SN - 1616-301X

VL - 28

JO - Advanced Functional Materials

JF - Advanced Functional Materials

IS - 12

M1 - 1605035

ER -

Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process

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Keywords

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