Abstract
The optimum conditions for the preparation of N-acetyl-S-nitrosopenicillamine (SNAP) 3 were determined and applied to the synthesis of the corresponding N-formyl compound 7. The nitrosation of penicillamine dipeptides was investigated and bis-thionitroso compounds 13, 18, 26 and 27 were isolated. S,S′-Dinitroso dithiol 13 showed biological activity akin to that of glyceryl trinitrate in decreasing systemic arterial blood pressure in anaesthetized rats and rabbits. Concomitant inhibition of collagen- or ADP-induced platelet aggregation was observed.
| Original language | English |
|---|---|
| Pages (from-to) | 797-805 |
| Number of pages | 9 |
| Journal | Journal of the Chemical Society, Perkin Transactions 1 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1994 |
| Externally published | Yes |
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