Prior information in fluorescence molecular tomography based on multispectral fluorescence emission

Research output: Chapter in Book/Report/Conference proceedingsChapterpeer-review

Abstract

Fluorescence molecular tomography (FMT) suffers from inherent ill-posedness due to the vast number of possible solutions to the reconstruction problem. To increase the robustness of such a problem one need prior information. We present here a method for rendering a priori information of the position of a fluorescent inclusion inside turbid media. The method utilizes solely two spectral bands within the fluorescence spectrum emitted from the fluorophore. The method is presented and verified using experimental data from a tissue phantom. The confinement is also used to impose weights onto the voxels before the inversion of the linear set of equations describing the FMT problem.

Original languageEnglish
Title of host publicationOptical Tomography and Spectroscopy of Tissue VII
DOIs
Publication statusPublished - 2007
Externally publishedYes
EventOptical Tomography and Spectroscopy of Tissue VII - San Jose, CA, United States
Duration: 21 Jan 200724 Jan 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6434
ISSN (Print)1605-7422

Conference

ConferenceOptical Tomography and Spectroscopy of Tissue VII
Country/TerritoryUnited States
CitySan Jose, CA
Period21/01/0724/01/07

Keywords

  • A priori information
  • Fluorescence molecular tomography
  • Fluorescence spectroscopy
  • Reconstruction schemes

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