TY - JOUR
T1 - Protocol for a systematic review of the diagnostic test accuracy of tests for IgE-mediated food allergy
AU - the EAACI Food Allergy Guidelines Expert Group, the EAACI Research, Outreach Committee Food Allergy Group
AU - Genuneit, Jon
AU - Jayasinghe, Sashini
AU - Riggioni, Carmen
AU - Peters, Rachel Louise
AU - Chu, Derek K.
AU - Munblit, Daniel
AU - Boyle, Robert J.
AU - Du Toit, George
AU - Skypala, Isabel
AU - Santos, Alexandra F.
AU - Akdis, Cezmi A.
AU - Alvarez-Perea, Alberto
AU - Lozano, Montserrat Alvaro
AU - Asero, Riccardo
AU - Ballmer-Weber, Barbara
AU - Barber, Domingo
AU - Barni, Simona
AU - Pajno, Giovanni Battista
AU - Beyer, Kirsten
AU - Bindslev-Jensen, Carsten
AU - Brough, Helen
AU - Buyuktiryaki, Betul
AU - de Oliveira, Lucila Camargo Lopes
AU - Cianferoni, Antonella
AU - Chinthrajah, R. Sharon
AU - Parker, Sean N.
AU - Giacco, Stefano Del
AU - DunnGalvin, Audrey
AU - Eberlein, Bernadette
AU - Ebisawa, Motohiro
AU - Eigenmann, Philippe
AU - Eiwegger, Thomas
AU - Faber, Margaretha
AU - Fernandez-Rivas, Montserrat
AU - Feeney, Mary
AU - Fisher, Helen
AU - Giovannini, Mattia
AU - Halken, Susanne
AU - Hoffmann-Sommergruber, Karin
AU - Jaumdally, Hannah
AU - Jones, Christina J.
AU - Knibb, Rebecca
AU - Knol, Edward
AU - Konstantinou, George N.
AU - Krawiec, Marta
AU - Lau, Susanne
AU - Mayorga, Lina
AU - Marques-Mejias, M. Andreina
AU - Meyer, Rosan
AU - O’Mahony, Liam
N1 - Publisher Copyright:
© 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
PY - 2022/1
Y1 - 2022/1
N2 - Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30 September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy. Methods: The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1 October 2012 to 30 June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluations will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food. Results: A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search. Discussion: Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.
AB - Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of updating the guidelines on the diagnosis and management of food allergy. The existing guidelines are based on a systematic review of the literature until 30 September 2012. Therefore, a new systematic review must be undertaken to inform the new guidelines. This systematic review aims to assess the accuracy of index tests to support the diagnosis of IgE-mediated food allergy. Methods: The databases Cochrane CENTRAL (Trials), MEDLINE (OVID) and Embase (OVID) will be searched for diagnostic test accuracy studies from 1 October 2012 to 30 June 2021. Inclusion and exclusion criteria will be used to select appropriate studies. Data from these studies will be extracted and tabulated, and then reviewed for risk of bias and applicability using the QUADAS-2 tool. All evaluations will be done in duplicate. Studies with a high risk of bias and low applicability will be excluded. Meta-analysis will be performed if there are three or more studies of the same index test and food. Results: A protocol for the systematic review and meta-analyses is presented and was registered using Prospero prior to commencing the literature search. Discussion: Oral food challenges are the reference standard for diagnosis but involve considerable risks and resources. This protocol for systematic review aims to assess the accuracy of various tests to diagnose food allergy, which can be useful in both clinical and research settings.
UR - https://www.scopus.com/pages/publications/85118650786
U2 - 10.1111/pai.13684
DO - 10.1111/pai.13684
M3 - Article
C2 - 34674299
AN - SCOPUS:85118650786
SN - 0905-6157
VL - 33
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
IS - 1
M1 - e13684
ER -