Quantitative EEG analysis in neonatal hypoxic ischaemic encephalopathy

Objective: To test the hypothesis that quantitative EEG (qEEG) measures are associated with a grading of HIE based on the visual interpretation of neonatal EEG (EEG/HIE). Methods: Continuous multichannel video-EEG data were recorded for up to 72. h. One-hour EEG segments from each recording were visually analysed and graded by two electroencephalographers (EEGers) blinded to clinical data. Several qEEG measures were calculated for each EEG segment. Kruskal-Wallis testing with post hoc analysis and multiple linear regression were used to assess the hypothesis. Results: Fifty-four full-term infants with HIE were studied. The relative delta power, skewness, kurtosis, amplitude, and discontinuity were significantly different across four EEG/HIE grades (p< 0.05). A linear combination of these qEEG measures could predict the EEG/HIE grade assigned by the EEGers with an accuracy of 89%. Conclusion: Quantitative analysis of background EEG activity has shown that measures based on the amplitude, frequency content and continuity of the EEG are associated with a visual interpretation of the EEG performed by experienced EEGers. Significance: Identifying qEEG measures that can separate between EEG/HIE grades is an important first step towards creating a classifier for automated detection of EEG/HIE grades.