TY - GEN
T1 - Quantra reproduces BI-RADS assessment on a two-point scale
AU - Ekpo, Ernest U.
AU - Mello-Thoms, Claudia
AU - Rickard, Mary
AU - Brennan, Patrick C.
AU - McEntee, Mark F.
N1 - Publisher Copyright:
© 2016 SPIE.
PY - 2016
Y1 - 2016
N2 - PURPOSE: To assess the performance of QuantraTM in reproducing BI-RADS® mammographic breast density (MBD) assessment. METHODS: Two methods of MBD assessment were used (QuantraTM and BI-RADS®). Volumetric breast density measurement from 292 raw projection images was performed using QuantraTM. BI-RADS® assessment was performed by three radiologists and a majority report (consensus of at least two radiologists) was generated. Interreader agreement (κ), agreement, and the sensitivity and specificity of QuantraTM in reproducing BI-RADS® rating were calculated on a four-grade (1, 2, 3, and 4) and two-grade (1-2 vs. 3-4) scale. RESULTS: The majority BI-RADS® report in the dataset consisted of 9.6% (n = 28), 35.3% (n = 103), 27.1% (n = 79), and 28.1% (n = 82) for BI-RADS® 1, 2, 3, and 4 respectively. Intra-reader agreement (κ) was 0.86 (95%CI: 0.83 - 0.91) to 0.88 (95%CI: 0.85 - 0.93) on a four-grade and 0.88 (95%CI: 0.83 - 0.92) to 0.91 (95%CI: 0.88 - 0.95) on a two-grade scale. Inter-reader agreement (κ) was substantial [0.66 (95%CI: 0.62 - 0.71) to 0.75 (95%CI: 0.70 - 0.81)] on a four-grade scale and substantial to almost perfect [0.77 (95%CI: 0.73 - 0.82) to 0.89 (95%CI: 0.84 - 0.93)] on a two-grade scale. QuantraTM correctly classified 35.7%, 91.2%, 88.6%, and 50.3% of BI-RADS® 1, 2, 3, and 4 respectively. It also demonstrated 91.3% sensitivity and 83.6% specificity in reproducing BI-RADS® on a two-grade scale (1-2 vs. 3-4). CONCLUSION: QuantraTM has limited performance in reproducing BI-RADS® rating on a four-grade scale, however, highly reproduces BI-RADS® assessment on a two-grade scale.
AB - PURPOSE: To assess the performance of QuantraTM in reproducing BI-RADS® mammographic breast density (MBD) assessment. METHODS: Two methods of MBD assessment were used (QuantraTM and BI-RADS®). Volumetric breast density measurement from 292 raw projection images was performed using QuantraTM. BI-RADS® assessment was performed by three radiologists and a majority report (consensus of at least two radiologists) was generated. Interreader agreement (κ), agreement, and the sensitivity and specificity of QuantraTM in reproducing BI-RADS® rating were calculated on a four-grade (1, 2, 3, and 4) and two-grade (1-2 vs. 3-4) scale. RESULTS: The majority BI-RADS® report in the dataset consisted of 9.6% (n = 28), 35.3% (n = 103), 27.1% (n = 79), and 28.1% (n = 82) for BI-RADS® 1, 2, 3, and 4 respectively. Intra-reader agreement (κ) was 0.86 (95%CI: 0.83 - 0.91) to 0.88 (95%CI: 0.85 - 0.93) on a four-grade and 0.88 (95%CI: 0.83 - 0.92) to 0.91 (95%CI: 0.88 - 0.95) on a two-grade scale. Inter-reader agreement (κ) was substantial [0.66 (95%CI: 0.62 - 0.71) to 0.75 (95%CI: 0.70 - 0.81)] on a four-grade scale and substantial to almost perfect [0.77 (95%CI: 0.73 - 0.82) to 0.89 (95%CI: 0.84 - 0.93)] on a two-grade scale. QuantraTM correctly classified 35.7%, 91.2%, 88.6%, and 50.3% of BI-RADS® 1, 2, 3, and 4 respectively. It also demonstrated 91.3% sensitivity and 83.6% specificity in reproducing BI-RADS® on a two-grade scale (1-2 vs. 3-4). CONCLUSION: QuantraTM has limited performance in reproducing BI-RADS® rating on a four-grade scale, however, highly reproduces BI-RADS® assessment on a two-grade scale.
KW - Breast density assessment
KW - Inter-reader agreement
KW - Mammography
KW - Volumetric breast density
UR - https://www.scopus.com/pages/publications/84976300428
U2 - 10.1117/12.2205391
DO - 10.1117/12.2205391
M3 - Conference proceeding
AN - SCOPUS:84976300428
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2016
A2 - Abbey, Craig K.
A2 - Kupinski, Matthew A.
PB - SPIE
T2 - Medical Imaging 2016: Image Perception, Observer Performance, and Technology Assessment
Y2 - 2 March 2016 through 3 March 2016
ER -