Quinoline Ligands Improve the Classic Direct C−H Functionalisation/Intramolecular Cyclisation of Diaryl Ethers to Dibenzofurans

Katrina Mackey; David J. Jones; Leticia M. Pardo; Gerard P. McGlacken

doi:10.1002/ejoc.202001416

Quinoline Ligands Improve the Classic Direct C−H Functionalisation/Intramolecular Cyclisation of Diaryl Ethers to Dibenzofurans

Katrina Mackey
, David J. Jones
, Leticia M. Pardo
, Gerard P. McGlacken

School of Chemistry

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

The C−H functionalisation approach to the synthesis of dibenzofurans is hampered by a number of problems. Herein we describe the evolution of a cheap, bench stable quinoline ligand, which obviates most of the current limitations and allows for a high yielding synthesis of a range of valuable dibenzofurans. Dibenzofurans are important motifs in natural products and compounds with wide biological activity.

Original language	Undefined/Unknown
Pages (from-to)	495-498
Number of pages	4
Journal	European Journal of Organic Chemistry
Volume	2021
Issue number	3
DOIs	https://doi.org/10.1002/ejoc.202001416
Publication status	Published - 22 Jan 2021

Keywords

Benzofurans
C−H functionalisation
Direct arylation
Homogeneous catalysis
Synthetic methods

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10.1002/ejoc.202001416

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title = "Quinoline Ligands Improve the Classic Direct C−H Functionalisation/Intramolecular Cyclisation of Diaryl Ethers to Dibenzofurans",

abstract = "The C−H functionalisation approach to the synthesis of dibenzofurans is hampered by a number of problems. Herein we describe the evolution of a cheap, bench stable quinoline ligand, which obviates most of the current limitations and allows for a high yielding synthesis of a range of valuable dibenzofurans. Dibenzofurans are important motifs in natural products and compounds with wide biological activity.",

keywords = "Benzofurans, C−H functionalisation, Direct arylation, Homogeneous catalysis, Synthetic methods",

author = "Katrina Mackey and Jones, \{David J.\} and Pardo, \{Leticia M.\} and McGlacken, \{Gerard P.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",

year = "2021",

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doi = "10.1002/ejoc.202001416",

language = "Undefined/Unknown",

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TY - JOUR

T1 - Quinoline Ligands Improve the Classic Direct C−H Functionalisation/Intramolecular Cyclisation of Diaryl Ethers to Dibenzofurans

AU - Mackey, Katrina

AU - Jones, David J.

AU - Pardo, Leticia M.

AU - McGlacken, Gerard P.

PY - 2021/1/22

Y1 - 2021/1/22

N2 - The C−H functionalisation approach to the synthesis of dibenzofurans is hampered by a number of problems. Herein we describe the evolution of a cheap, bench stable quinoline ligand, which obviates most of the current limitations and allows for a high yielding synthesis of a range of valuable dibenzofurans. Dibenzofurans are important motifs in natural products and compounds with wide biological activity.

AB - The C−H functionalisation approach to the synthesis of dibenzofurans is hampered by a number of problems. Herein we describe the evolution of a cheap, bench stable quinoline ligand, which obviates most of the current limitations and allows for a high yielding synthesis of a range of valuable dibenzofurans. Dibenzofurans are important motifs in natural products and compounds with wide biological activity.

KW - Benzofurans

KW - C−H functionalisation

KW - Direct arylation

KW - Homogeneous catalysis

KW - Synthetic methods

UR - https://doi.org/10.1002/ejoc.202001416

UR - https://www.scopus.com/pages/publications/85099041074

U2 - 10.1002/ejoc.202001416

DO - 10.1002/ejoc.202001416

M3 - Article

SN - 1434-193X

VL - 2021

SP - 495

EP - 498

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 3

ER -

Quinoline Ligands Improve the Classic Direct C−H Functionalisation/Intramolecular Cyclisation of Diaryl Ethers to Dibenzofurans

Abstract

Keywords

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