Rückfallprävention bipolarer Störungen: ein clusteranalytischer Ansatz bei einer randomisierten, kontrollierten Psychotherapiestudie

Thomas J. Stamm; J. Fiebig; G. O. Malley; L. M. Sondergeld; P. Treu; F. Bermpohl; E. Friedel; G. Hindi-Attar; E. Quinlivian; S. Schreiter; A. Wietzke; T. Ethofer; A. Fallgatter; I. Lang; E. Beck; K. Krisch; I. Kunze; R. Niebler; J. Zwick; V. Kraft; M. Lambert; Rohenkohl; F. Rühl; M. Bauer; J. Conell; L. Jurjanz; D. Ritter; P. Ritter; M. Spreer; S. Biere; N. Goldbach; S. Kittel-Schneider; S. Matura; V. Oertel; A. Reif; I. Falkenberg; T. Kircher; I. Kluge; S. Mehl; E. Poll; K. Adorjan; M. Heilbronner; J. Kálmán; F. Klöhn-Saghatolislam; T. G. Schulze; F. Senner; O. Gruber; L. Heß; S. Trost; C. Werner; S. Wolter; M. Hautzinger

doi:10.1007/s00115-024-01720-7

Rückfallprävention bipolarer Störungen: ein clusteranalytischer Ansatz bei einer randomisierten, kontrollierten Psychotherapiestudie

Translated title of the contribution: Relapse prevention of bipolar disorders: a cluster analytical approach in a randomized controlled psychotherapy study

Thomas J. Stamm
, J. Fiebig
, G. O. Malley
, L. M. Sondergeld
, P. Treu
, F. Bermpohl
, E. Friedel
, G. Hindi-Attar
, E. Quinlivian
, S. Schreiter
, A. Wietzke
, T. Ethofer
, A. Fallgatter
, I. Lang
, E. Beck
, K. Krisch
, I. Kunze
, R. Niebler
, J. Zwick
, V. Kraft

M. Lambert, Rohenkohl, F. Rühl, M. Bauer, J. Conell, L. Jurjanz, D. Ritter, P. Ritter, M. Spreer, S. Biere, N. Goldbach, S. Kittel-Schneider, S. Matura, V. Oertel, A. Reif, I. Falkenberg, T. Kircher, I. Kluge, S. Mehl, E. Poll, K. Adorjan, M. Heilbronner, J. Kálmán, F. Klöhn-Saghatolislam, T. G. Schulze, F. Senner, O. Gruber, L. Heß, S. Trost, C. Werner, S. Wolter, M. Hautzinger

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this study was to differentiate between types of bipolar disorders and the associated features using explorative analysis. The focus was particularly on the role of bipolar 1 and bipolar 2 disorders as well as the influence of prophylactic interventions for relapse in a randomized, controlled treatment study. A total of 274 of the 305 originally included persons could be investigated in the study. Patients participated in either cognitive behavioral group therapy (SEKT) or supportive, patient-centered group therapy (FEST). Treatment took place over 4 days separated by a 1-month interval (equivalent to 16 double hours). Depressive and manic symptoms were assessed using the longitudinal interval follow-up evaluation (LIFE). The symptoms were retrospectively assessed for the previous 6 months, with respect to each week before and after the intervention phase and for 6‑month and 12-month follow-ups. The results show that the effects of both group therapies were comparable; however, there were statistically significant differences in a multivariate proportional hazards model for the factors bipolar 1 and 2 as well as the interaction of therapy with bipolar 1 and 2. In particular, bipolar 2 patients benefited significantly less from the SEKT intervention than from the FEST intervention. There were three clusters identified that separated bipolar 1 (SEKT, no comorbidity, predominantly no recurrences, younger patients), from bipolar 2 (FEST, no comorbidity, at least 1 often 2 recurrences, older patients) and from a heterogeneous group (SEKT and FEST, comorbidity). The distinction between bipolar 1 and bipolar 2 disorder is important and has so far not received sufficient attention. Bipolar 2 disorders generally have a worse course and respond particularly poorly to cognitive behavioral therapy (SEKT). An open, unstructured, supportive, patient-centered psychotherapy (FEST) is generally effective.

Translated title of the contribution	Relapse prevention of bipolar disorders: a cluster analytical approach in a randomized controlled psychotherapy study
Original language	German
Pages (from-to)	471-479
Number of pages	9
Journal	Der Nervenarzt
Volume	96
Issue number	5
DOIs	https://doi.org/10.1007/s00115-024-01720-7
Publication status	Published - Sep 2025
Externally published	Yes

Keywords

Bipolar 1 disorder
Bipolar 2 disorder
Cognitive behavior therapy
Relapse prevention
Supportive psychotherapy

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10.1007/s00115-024-01720-7

Cite this

Stamm, T. J., Fiebig, J., Malley, G. O., Sondergeld, L. M., Treu, P., Bermpohl, F., Friedel, E., Hindi-Attar, G., Quinlivian, E., Schreiter, S., Wietzke, A., Ethofer, T., Fallgatter, A., Lang, I., Beck, E., Krisch, K., Kunze, I., Niebler, R., Zwick, J., ... Hautzinger, M. (2025). Rückfallprävention bipolarer Störungen: ein clusteranalytischer Ansatz bei einer randomisierten, kontrollierten Psychotherapiestudie. Der Nervenarzt, 96(5), 471-479. https://doi.org/10.1007/s00115-024-01720-7

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title = "R{\"u}ckfallpr{\"a}vention bipolarer St{\"o}rungen: ein clusteranalytischer Ansatz bei einer randomisierten, kontrollierten Psychotherapiestudie",

abstract = "The aim of this study was to differentiate between types of bipolar disorders and the associated features using explorative analysis. The focus was particularly on the role of bipolar 1 and bipolar 2 disorders as well as the influence of prophylactic interventions for relapse in a randomized, controlled treatment study. A total of 274 of the 305 originally included persons could be investigated in the study. Patients participated in either cognitive behavioral group therapy (SEKT) or supportive, patient-centered group therapy (FEST). Treatment took place over 4 days separated by a 1-month interval (equivalent to 16 double hours). Depressive and manic symptoms were assessed using the longitudinal interval follow-up evaluation (LIFE). The symptoms were retrospectively assessed for the previous 6 months, with respect to each week before and after the intervention phase and for 6‑month and 12-month follow-ups. The results show that the effects of both group therapies were comparable; however, there were statistically significant differences in a multivariate proportional hazards model for the factors bipolar 1 and 2 as well as the interaction of therapy with bipolar 1 and 2. In particular, bipolar 2 patients benefited significantly less from the SEKT intervention than from the FEST intervention. There were three clusters identified that separated bipolar 1 (SEKT, no comorbidity, predominantly no recurrences, younger patients), from bipolar 2 (FEST, no comorbidity, at least 1 often 2 recurrences, older patients) and from a heterogeneous group (SEKT and FEST, comorbidity). The distinction between bipolar 1 and bipolar 2 disorder is important and has so far not received sufficient attention. Bipolar 2 disorders generally have a worse course and respond particularly poorly to cognitive behavioral therapy (SEKT). An open, unstructured, supportive, patient-centered psychotherapy (FEST) is generally effective.",

keywords = "Bipolar 1 disorder, Bipolar 2 disorder, Cognitive behavior therapy, Relapse prevention, Supportive psychotherapy",

author = "Stamm, \{Thomas J.\} and J. Fiebig and Malley, \{G. O.\} and Sondergeld, \{L. M.\} and P. Treu and F. Bermpohl and E. Friedel and G. Hindi-Attar and E. Quinlivian and S. Schreiter and A. Wietzke and T. Ethofer and A. Fallgatter and I. Lang and E. Beck and K. Krisch and I. Kunze and R. Niebler and J. Zwick and V. Kraft and M. Lambert and Rohenkohl and F. R{\"u}hl and M. Bauer and J. Conell and L. Jurjanz and D. Ritter and P. Ritter and M. Spreer and S. Biere and N. Goldbach and S. Kittel-Schneider and S. Matura and V. Oertel and A. Reif and I. Falkenberg and T. Kircher and I. Kluge and S. Mehl and E. Poll and K. Adorjan and M. Heilbronner and J. K{\'a}lm{\'a}n and F. Kl{\"o}hn-Saghatolislam and Schulze, \{T. G.\} and F. Senner and O. Gruber and L. He{\ss} and S. Trost and C. Werner and S. Wolter and M. Hautzinger",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2025",

month = sep,

doi = "10.1007/s00115-024-01720-7",

language = "German",

volume = "96",

pages = "471--479",

journal = "Der Nervenarzt",

issn = "0028-2804",

publisher = "Springer Medizin",

number = "5",

}

Stamm, TJ, Fiebig, J, Malley, GO, Sondergeld, LM, Treu, P, Bermpohl, F, Friedel, E, Hindi-Attar, G, Quinlivian, E, Schreiter, S, Wietzke, A, Ethofer, T, Fallgatter, A, Lang, I, Beck, E, Krisch, K, Kunze, I, Niebler, R, Zwick, J, Kraft, V, Lambert, M, Rohenkohl, Rühl, F, Bauer, M, Conell, J, Jurjanz, L, Ritter, D, Ritter, P, Spreer, M, Biere, S, Goldbach, N, Kittel-Schneider, S, Matura, S, Oertel, V, Reif, A, Falkenberg, I, Kircher, T, Kluge, I, Mehl, S, Poll, E, Adorjan, K, Heilbronner, M, Kálmán, J, Klöhn-Saghatolislam, F, Schulze, TG, Senner, F, Gruber, O, Heß, L, Trost, S, Werner, C, Wolter, S & Hautzinger, M 2025, 'Rückfallprävention bipolarer Störungen: ein clusteranalytischer Ansatz bei einer randomisierten, kontrollierten Psychotherapiestudie', Der Nervenarzt, vol. 96, no. 5, pp. 471-479. https://doi.org/10.1007/s00115-024-01720-7

TY - JOUR

T1 - Rückfallprävention bipolarer Störungen

T2 - ein clusteranalytischer Ansatz bei einer randomisierten, kontrollierten Psychotherapiestudie

AU - Stamm, Thomas J.

AU - Fiebig, J.

AU - Malley, G. O.

AU - Sondergeld, L. M.

AU - Treu, P.

AU - Bermpohl, F.

AU - Friedel, E.

AU - Hindi-Attar, G.

AU - Quinlivian, E.

AU - Schreiter, S.

AU - Wietzke, A.

AU - Ethofer, T.

AU - Fallgatter, A.

AU - Lang, I.

AU - Beck, E.

AU - Krisch, K.

AU - Kunze, I.

AU - Niebler, R.

AU - Zwick, J.

AU - Kraft, V.

AU - Lambert, M.

AU - Rohenkohl,

AU - Rühl, F.

AU - Bauer, M.

AU - Conell, J.

AU - Jurjanz, L.

AU - Ritter, D.

AU - Ritter, P.

AU - Spreer, M.

AU - Biere, S.

AU - Goldbach, N.

AU - Kittel-Schneider, S.

AU - Matura, S.

AU - Oertel, V.

AU - Reif, A.

AU - Falkenberg, I.

AU - Kircher, T.

AU - Kluge, I.

AU - Mehl, S.

AU - Poll, E.

AU - Adorjan, K.

AU - Heilbronner, M.

AU - Kálmán, J.

AU - Klöhn-Saghatolislam, F.

AU - Schulze, T. G.

AU - Senner, F.

AU - Gruber, O.

AU - Heß, L.

AU - Trost, S.

AU - Werner, C.

AU - Wolter, S.

AU - Hautzinger, M.

PY - 2025/9

Y1 - 2025/9

N2 - The aim of this study was to differentiate between types of bipolar disorders and the associated features using explorative analysis. The focus was particularly on the role of bipolar 1 and bipolar 2 disorders as well as the influence of prophylactic interventions for relapse in a randomized, controlled treatment study. A total of 274 of the 305 originally included persons could be investigated in the study. Patients participated in either cognitive behavioral group therapy (SEKT) or supportive, patient-centered group therapy (FEST). Treatment took place over 4 days separated by a 1-month interval (equivalent to 16 double hours). Depressive and manic symptoms were assessed using the longitudinal interval follow-up evaluation (LIFE). The symptoms were retrospectively assessed for the previous 6 months, with respect to each week before and after the intervention phase and for 6‑month and 12-month follow-ups. The results show that the effects of both group therapies were comparable; however, there were statistically significant differences in a multivariate proportional hazards model for the factors bipolar 1 and 2 as well as the interaction of therapy with bipolar 1 and 2. In particular, bipolar 2 patients benefited significantly less from the SEKT intervention than from the FEST intervention. There were three clusters identified that separated bipolar 1 (SEKT, no comorbidity, predominantly no recurrences, younger patients), from bipolar 2 (FEST, no comorbidity, at least 1 often 2 recurrences, older patients) and from a heterogeneous group (SEKT and FEST, comorbidity). The distinction between bipolar 1 and bipolar 2 disorder is important and has so far not received sufficient attention. Bipolar 2 disorders generally have a worse course and respond particularly poorly to cognitive behavioral therapy (SEKT). An open, unstructured, supportive, patient-centered psychotherapy (FEST) is generally effective.

AB - The aim of this study was to differentiate between types of bipolar disorders and the associated features using explorative analysis. The focus was particularly on the role of bipolar 1 and bipolar 2 disorders as well as the influence of prophylactic interventions for relapse in a randomized, controlled treatment study. A total of 274 of the 305 originally included persons could be investigated in the study. Patients participated in either cognitive behavioral group therapy (SEKT) or supportive, patient-centered group therapy (FEST). Treatment took place over 4 days separated by a 1-month interval (equivalent to 16 double hours). Depressive and manic symptoms were assessed using the longitudinal interval follow-up evaluation (LIFE). The symptoms were retrospectively assessed for the previous 6 months, with respect to each week before and after the intervention phase and for 6‑month and 12-month follow-ups. The results show that the effects of both group therapies were comparable; however, there were statistically significant differences in a multivariate proportional hazards model for the factors bipolar 1 and 2 as well as the interaction of therapy with bipolar 1 and 2. In particular, bipolar 2 patients benefited significantly less from the SEKT intervention than from the FEST intervention. There were three clusters identified that separated bipolar 1 (SEKT, no comorbidity, predominantly no recurrences, younger patients), from bipolar 2 (FEST, no comorbidity, at least 1 often 2 recurrences, older patients) and from a heterogeneous group (SEKT and FEST, comorbidity). The distinction between bipolar 1 and bipolar 2 disorder is important and has so far not received sufficient attention. Bipolar 2 disorders generally have a worse course and respond particularly poorly to cognitive behavioral therapy (SEKT). An open, unstructured, supportive, patient-centered psychotherapy (FEST) is generally effective.

KW - Bipolar 1 disorder

KW - Bipolar 2 disorder

KW - Cognitive behavior therapy

KW - Relapse prevention

KW - Supportive psychotherapy

UR - https://www.scopus.com/pages/publications/85206900543

U2 - 10.1007/s00115-024-01720-7

DO - 10.1007/s00115-024-01720-7

M3 - Article

C2 - 39172251

AN - SCOPUS:85206900543

SN - 0028-2804

VL - 96

SP - 471

EP - 479

JO - Der Nervenarzt

JF - Der Nervenarzt

IS - 5

ER -

Rückfallprävention bipolarer Störungen: ein clusteranalytischer Ansatz bei einer randomisierten, kontrollierten Psychotherapiestudie

Abstract

Keywords

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