Rapid Quantification of NaDCC for Water Purification Tablets in Commercial Production Using ATR-FTIR Spectroscopy Based on Machine Learning Techniques

Accurate, fast and simple quantitative analysis of solid dosage forms is required for efficient pharmaceutical manufacturing. A spectroscopic analysis in ATR-FTIR (Attenuated Total Reflection-Fourier Transform Infrared) mode was developed for NaDCC (Sodium dichloroisocyanurate) quantification. This fast and low-cost method can be used to quantify NaDCC solid dosage forms using ATR-FTIR in absorbance mode in conjunction with partial least squares. A simple sampling procedure is included in the proposed experiment by just dissolving the samples in deionized water. An algorithm pipeline is also included for data cleaning, such as outlier removal, scatter correction, scaling, and mapping of the sample’s spectrum to a NaDCC concentration. In addition, a simple model based on Beer’s law was evaluated on a sub-range of. Furthermore, a variable selection algorithm shows minimum excipient interference from the sample matrix in addition to visual analysis. A statistical analysis of the proposed method shows that it demonstrates a promising result with a regression coefficient of 0.996 and recovery range of 95.5%–107%. As a result of the positive correlation of ATR-FTIR with NaDCC concentration, and in conjunction with the proposed method, this can serve as a clean, fast, affordable and eco-friendly method for pharmaceutical analysis.