Regioselective iridium-catalyzed C(7)–H borylation of free N–H 6-fluoroquinolones

Eimear Courtney; James  Mulcahy; Aobha Hickey; Julia Mertz; Mark Light; Todd B. Marder; Gerard P. McGlacken

doi:10.1021/acsomega.5c11604

Regioselective iridium-catalyzed C(7)–H borylation of free N–H 6-fluoroquinolones

Eimear Courtney
, James Mulcahy
, Aobha Hickey
, Julia Mertz
, Mark Light
, Todd B. Marder
, Gerard P. McGlacken

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Quinolones are widely used as antibiotics, with 6-fluoroquinolones representing a particularly prominent class. In this work, we present an iridium-catalyzed C–H borylation strategy for unprotected NH 6-fluoroquinolones, achieving good yields and enabling efficient functionalization at the critical 7-position.

Original language	English
Pages (from-to)	25149-25155
Number of pages	7
Journal	ACS Omega
Volume	11
Issue number	17
DOIs	https://doi.org/10.1021/acsomega.5c11604
Publication status	Published - 23 Apr 2026

Keywords

Iridium-catalyzed C−H borylation strategy for unprotected NH 6-fluoroquinolones
[Chemistry]

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10.1021/acsomega.5c11604Licence: CC BY-NC-ND

regioselective-iridium-catalyzed-c(7)-h-borylation-of-free-n-h-6-fluoroquinolonesFinal published version, 3.44 MBLicence: CC BY-NC-ND

https://www.scopus.com/pages/publications/105037872086?origin=resultslist

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@article{43799926ef6e4ed9a070c12a6e963164,

title = "Regioselective iridium-catalyzed C(7){\textendash}H borylation of free N{\textendash}H 6-fluoroquinolones",

abstract = "Quinolones are widely used as antibiotics, with 6-fluoroquinolones representing a particularly prominent class. In this work, we present an iridium-catalyzed C{\textendash}H borylation strategy for unprotected NH 6-fluoroquinolones, achieving good yields and enabling efficient functionalization at the critical 7-position. ",

keywords = "Iridium-catalyzed C−H borylation strategy for unprotected NH 6-fluoroquinolones, [Chemistry]",

author = "Eimear Courtney and James Mulcahy and Aobha Hickey and Julia Mertz and Mark Light and Marder, \{Todd B.\} and McGlacken, \{Gerard P.\}",

note = "{\textcopyright} 2026, the Authors. Published by American Chemical Society.",

year = "2026",

month = apr,

day = "23",

doi = "10.1021/acsomega.5c11604",

language = "English",

volume = "11",

pages = "25149--25155",

journal = "ACS Omega",

issn = "2470-1343",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Regioselective iridium-catalyzed C(7)–H borylation of free N–H 6-fluoroquinolones

AU - Courtney, Eimear

AU - Mulcahy, James

AU - Hickey, Aobha

AU - Mertz, Julia

AU - Light, Mark

AU - Marder, Todd B.

AU - McGlacken, Gerard P.

PY - 2026/4/23

Y1 - 2026/4/23

N2 - Quinolones are widely used as antibiotics, with 6-fluoroquinolones representing a particularly prominent class. In this work, we present an iridium-catalyzed C–H borylation strategy for unprotected NH 6-fluoroquinolones, achieving good yields and enabling efficient functionalization at the critical 7-position.

AB - Quinolones are widely used as antibiotics, with 6-fluoroquinolones representing a particularly prominent class. In this work, we present an iridium-catalyzed C–H borylation strategy for unprotected NH 6-fluoroquinolones, achieving good yields and enabling efficient functionalization at the critical 7-position.

KW - Iridium-catalyzed C−H borylation strategy for unprotected NH 6-fluoroquinolones

KW - [Chemistry]

U2 - 10.1021/acsomega.5c11604

DO - 10.1021/acsomega.5c11604

M3 - Article

SN - 2470-1343

VL - 11

SP - 25149

EP - 25155

JO - ACS Omega

JF - ACS Omega

IS - 17

ER -

Regioselective iridium-catalyzed C(7)–H borylation of free N–H 6-fluoroquinolones

Abstract

Keywords

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