Relationship between TLR-2 mRNA and TLR-2 levels and variations of the immunoglobulin profile in the urogenital tract of women with urogenital chlamydiasis

Women with urogenital chlamydiasis (UGC) presented with enhanced expression of TLR-2 and TLR-4 genes, altered IgG, IgM. IgA, and slgA levels, as well as secretory component (SC) content in the cervical canal (CC) that correlated with the frequency and severity of clinical manifestations. High TRL-2 and TRL-4 expression, leukocyte count, protein and immunoglobulin content in patients with acute UGC may be regarded as an expressed local immune response of the macroorganism that reflects severity of the acute pathological condition. The growth of IgG level in the cervical secretion (CS) is associated with serum exudation through mucosa whereas the presence of slgA and SC may result from their local synthesis. Impaired expression of TLR-2 and TLR-4, low leukocyte count, reduced production of protein, slgA, and SC in the patients are attributable to suppression of local immunity. High IgG and protein levels in cervical secretion coupled to the enhanced leukocyte reaction in the cervical canal suggest chronic inflammatory process associated with chlamydial infection.. Recovery after urogenital chlamydiasis does not completely eliminate residual manifestations of disturbed local Immunity in CC as evidenced by the level of humoral factors and leukocyte count.