RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

R. Alexander Wesselhoeft; Piotr S. Kowalski; Frances C. Parker-Hale; Yuxuan Huang; Namita Bisaria; Daniel G. Anderson

doi:10.1016/j.molcel.2019.02.015

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

R. Alexander Wesselhoeft
, Piotr S. Kowalski
, Frances C. Parker-Hale
, Yuxuan Huang
, Namita Bisaria
, Daniel G. Anderson

Massachusetts Institute of Technology
Whitehead Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the potential of circRNA as a vector for therapeutic gene expression.

Original language	English
Pages (from-to)	508-520.e4
Journal	Molecular Cell
Volume	74
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2019.02.015
Publication status	Published - 2 May 2019
Externally published	Yes

Keywords

circular RNA
immunogenicity
protein expression
RIG-I
RNA sensors
synthetic

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10.1016/j.molcel.2019.02.015

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title = "RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo",

abstract = "Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the potential of circRNA as a vector for therapeutic gene expression.",

keywords = "circular RNA, immunogenicity, protein expression, RIG-I, RNA sensors, synthetic",

author = "Wesselhoeft, \{R. Alexander\} and Kowalski, \{Piotr S.\} and Parker-Hale, \{Frances C.\} and Yuxuan Huang and Namita Bisaria and Anderson, \{Daniel G.\}",

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AU - Parker-Hale, Frances C.

AU - Huang, Yuxuan

AU - Bisaria, Namita

AU - Anderson, Daniel G.

PY - 2019/5/2

Y1 - 2019/5/2

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AB - Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the potential of circRNA as a vector for therapeutic gene expression.

KW - circular RNA

KW - immunogenicity

KW - protein expression

KW - RIG-I

KW - RNA sensors

KW - synthetic

UR - https://www.scopus.com/pages/publications/85063032191

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DO - 10.1016/j.molcel.2019.02.015

M3 - Article

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SP - 508-520.e4

JO - Molecular Cell

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ER -

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo

Abstract

Keywords

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