Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Jennifer Chu; Wenhan Zhang; Regina Cencic; Patrick B.F. O'Connor; Francis Robert; William G. Devine; Asher Selznick; Thomas Henkel; William C. Merrick; Lauren E. Brown; Pavel V. Baranov; John A. Porco; Jerry Pelletier

doi:10.1016/j.celrep.2020.02.002

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Jennifer Chu
, Wenhan Zhang
, Regina Cencic
, Patrick B.F. O'Connor
, Francis Robert
, William G. Devine
, Asher Selznick
, Thomas Henkel
, William C. Merrick
, Lauren E. Brown
, Pavel V. Baranov
, John A. Porco
, Jerry Pelletier

School of Biochemistry and Cell Biology

McGill University
Boston University
IMAX Discovery GmbH
Case Western Reserve University
Russian Academy of Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Rocaglates are a diverse family of small molecules that inhibit eIF4A. Chu et al. undertake a comparative analysis of the bioactivity of >200 rocaglates and uncover nuances in their mechanisms of action. Rocaglates interfere with eIF4F release from the cap and exert a bystander effect to inhibit translation.

Original language	English
Pages (from-to)	2481-2488.e5
Journal	Cell Reports
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.celrep.2020.02.002
Publication status	Published - 25 Feb 2020

Keywords

eIF4A
eIF4F
interfacial inhibitor
rocaglates
translation initiation

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10.1016/j.celrep.2020.02.002

https://hdl.handle.net/10468/13372Licence: CC BY-NC-ND

Cite this

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title = "Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F",

abstract = "Rocaglates are a diverse family of small molecules that inhibit eIF4A. Chu et al. undertake a comparative analysis of the bioactivity of >200 rocaglates and uncover nuances in their mechanisms of action. Rocaglates interfere with eIF4F release from the cap and exert a bystander effect to inhibit translation.",

keywords = "eIF4A, eIF4F, interfacial inhibitor, rocaglates, translation initiation",

author = "Jennifer Chu and Wenhan Zhang and Regina Cencic and O'Connor, \{Patrick B.F.\} and Francis Robert and Devine, \{William G.\} and Asher Selznick and Thomas Henkel and Merrick, \{William C.\} and Brown, \{Lauren E.\} and Baranov, \{Pavel V.\} and Porco, \{John A.\} and Jerry Pelletier",

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doi = "10.1016/j.celrep.2020.02.002",

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T1 - Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

AU - Chu, Jennifer

AU - Zhang, Wenhan

AU - Cencic, Regina

AU - O'Connor, Patrick B.F.

AU - Robert, Francis

AU - Devine, William G.

AU - Selznick, Asher

AU - Henkel, Thomas

AU - Merrick, William C.

AU - Brown, Lauren E.

AU - Baranov, Pavel V.

AU - Porco, John A.

AU - Pelletier, Jerry

PY - 2020/2/25

Y1 - 2020/2/25

N2 - Rocaglates are a diverse family of small molecules that inhibit eIF4A. Chu et al. undertake a comparative analysis of the bioactivity of >200 rocaglates and uncover nuances in their mechanisms of action. Rocaglates interfere with eIF4F release from the cap and exert a bystander effect to inhibit translation.

AB - Rocaglates are a diverse family of small molecules that inhibit eIF4A. Chu et al. undertake a comparative analysis of the bioactivity of >200 rocaglates and uncover nuances in their mechanisms of action. Rocaglates interfere with eIF4F release from the cap and exert a bystander effect to inhibit translation.

KW - eIF4A

KW - eIF4F

KW - interfacial inhibitor

KW - rocaglates

KW - translation initiation

UR - https://www.scopus.com/pages/publications/85080097457

U2 - 10.1016/j.celrep.2020.02.002

DO - 10.1016/j.celrep.2020.02.002

M3 - Article

C2 - 32101697

AN - SCOPUS:85080097457

SN - 2639-1856

VL - 30

SP - 2481-2488.e5

JO - Cell Reports

JF - Cell Reports

IS - 8

ER -

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F

Abstract

Keywords

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