@article{ceac34d2a5b1437bb3ad22bf9c8609a5,
title = "Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F",
abstract = "Rocaglates are a diverse family of small molecules that inhibit eIF4A. Chu et al. undertake a comparative analysis of the bioactivity of >200 rocaglates and uncover nuances in their mechanisms of action. Rocaglates interfere with eIF4F release from the cap and exert a bystander effect to inhibit translation.",
keywords = "eIF4A, eIF4F, interfacial inhibitor, rocaglates, translation initiation",
author = "Jennifer Chu and Wenhan Zhang and Regina Cencic and O'Connor, \{Patrick B.F.\} and Francis Robert and Devine, \{William G.\} and Asher Selznick and Thomas Henkel and Merrick, \{William C.\} and Brown, \{Lauren E.\} and Baranov, \{Pavel V.\} and Porco, \{John A.\} and Jerry Pelletier",
note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = feb,
day = "25",
doi = "10.1016/j.celrep.2020.02.002",
language = "English",
volume = "30",
pages = "2481--2488.e5",
journal = "Cell Reports",
issn = "2639-1856",
publisher = "Elsevier B.V.",
number = "8",
}
