Role of oxidative stress and mitochondrial dysfunction in skeletal muscle in type 2 diabetic patients

Noelia Diaz-Morales; Susana Rovira-Llopis; Irene Escribano-Lopez; Celia Bañuls; Sandra Lopez-Domenech; Rosa Falcón; Arantxa Martinez De Marañon; Eva Sola; Ana Jover; Ildefonso Roldan; Jose L. Diez; Milagros Rocha; Antonio Hernández-Mijares; Victor M. Víctor

doi:10.2174/1381612822666160217142949

Role of oxidative stress and mitochondrial dysfunction in skeletal muscle in type 2 diabetic patients

Noelia Diaz-Morales
, Susana Rovira-Llopis
, Irene Escribano-Lopez
, Celia Bañuls
, Sandra Lopez-Domenech
, Rosa Falcón
, Arantxa Martinez De Marañon
, Eva Sola
, Ana Jover
, Ildefonso Roldan
, Jose L. Diez
, Milagros Rocha
, Antonio Hernández-Mijares
, Victor M. Víctor

Research output: Contribution to journal › Article › peer-review

Abstract

Type 2 diabetes can increase the risk of skeletal muscle dysfunction and, consequently, that of cardiovascular diseases, including coronary artery disease and stroke. It is also related to a reduced capacity for exercise, but the underlying mechanism is only partially understood. There are several factors that contribute to the development of skeletal muscle dysfunction, of which oxidative stress and mitochondrial dysfunction are among the most important. This review discusses the role of oxidative stress in the development and progression of skeletal and cardiac dysfunction associated with diabetes. It also provides an overview of the potential actions of antioxidants in general and mitochondria-targeted antioxidants in particular in the treatment of muscle dysfunction in type 2 diabetes.

Original language	English
Pages (from-to)	2650-2656
Number of pages	7
Journal	Current Pharmaceutical Design
Volume	22
Issue number	18
DOIs	https://doi.org/10.2174/1381612822666160217142949
Publication status	Published - 1 May 2016
Externally published	Yes

Keywords

Antioxidants
Mitochondria
Muscle
Oxidative stress
Type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/1381612822666160217142949

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Diaz-Morales, N., Rovira-Llopis, S., Escribano-Lopez, I., Bañuls, C., Lopez-Domenech, S., Falcón, R., De Marañon, A. M., Sola, E., Jover, A., Roldan, I., Diez, J. L., Rocha, M., Hernández-Mijares, A., & Víctor, V. M. (2016). Role of oxidative stress and mitochondrial dysfunction in skeletal muscle in type 2 diabetic patients. Current Pharmaceutical Design, 22(18), 2650-2656. https://doi.org/10.2174/1381612822666160217142949

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title = "Role of oxidative stress and mitochondrial dysfunction in skeletal muscle in type 2 diabetic patients",

abstract = "Type 2 diabetes can increase the risk of skeletal muscle dysfunction and, consequently, that of cardiovascular diseases, including coronary artery disease and stroke. It is also related to a reduced capacity for exercise, but the underlying mechanism is only partially understood. There are several factors that contribute to the development of skeletal muscle dysfunction, of which oxidative stress and mitochondrial dysfunction are among the most important. This review discusses the role of oxidative stress in the development and progression of skeletal and cardiac dysfunction associated with diabetes. It also provides an overview of the potential actions of antioxidants in general and mitochondria-targeted antioxidants in particular in the treatment of muscle dysfunction in type 2 diabetes.",

keywords = "Antioxidants, Mitochondria, Muscle, Oxidative stress, Type 2 diabetes",

author = "Noelia Diaz-Morales and Susana Rovira-Llopis and Irene Escribano-Lopez and Celia Ba{\~n}uls and Sandra Lopez-Domenech and Rosa Falc{\'o}n and \{De Mara{\~n}on\}, \{Arantxa Martinez\} and Eva Sola and Ana Jover and Ildefonso Roldan and Diez, \{Jose L.\} and Milagros Rocha and Antonio Hern{\'a}ndez-Mijares and V{\'i}ctor, \{Victor M.\}",

note = "Publisher Copyright: {\textcopyright} 2016 Bentham Science Publishers.",

year = "2016",

month = may,

day = "1",

doi = "10.2174/1381612822666160217142949",

language = "English",

volume = "22",

pages = "2650--2656",

journal = "Current Pharmaceutical Design",

issn = "1381-6128",

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Diaz-Morales, N, Rovira-Llopis, S, Escribano-Lopez, I, Bañuls, C, Lopez-Domenech, S, Falcón, R, De Marañon, AM, Sola, E, Jover, A, Roldan, I, Diez, JL, Rocha, M, Hernández-Mijares, A & Víctor, VM 2016, 'Role of oxidative stress and mitochondrial dysfunction in skeletal muscle in type 2 diabetic patients', Current Pharmaceutical Design, vol. 22, no. 18, pp. 2650-2656. https://doi.org/10.2174/1381612822666160217142949

TY - JOUR

T1 - Role of oxidative stress and mitochondrial dysfunction in skeletal muscle in type 2 diabetic patients

AU - Diaz-Morales, Noelia

AU - Rovira-Llopis, Susana

AU - Escribano-Lopez, Irene

AU - Bañuls, Celia

AU - Lopez-Domenech, Sandra

AU - Falcón, Rosa

AU - De Marañon, Arantxa Martinez

AU - Sola, Eva

AU - Jover, Ana

AU - Roldan, Ildefonso

AU - Diez, Jose L.

AU - Rocha, Milagros

AU - Hernández-Mijares, Antonio

AU - Víctor, Victor M.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Type 2 diabetes can increase the risk of skeletal muscle dysfunction and, consequently, that of cardiovascular diseases, including coronary artery disease and stroke. It is also related to a reduced capacity for exercise, but the underlying mechanism is only partially understood. There are several factors that contribute to the development of skeletal muscle dysfunction, of which oxidative stress and mitochondrial dysfunction are among the most important. This review discusses the role of oxidative stress in the development and progression of skeletal and cardiac dysfunction associated with diabetes. It also provides an overview of the potential actions of antioxidants in general and mitochondria-targeted antioxidants in particular in the treatment of muscle dysfunction in type 2 diabetes.

AB - Type 2 diabetes can increase the risk of skeletal muscle dysfunction and, consequently, that of cardiovascular diseases, including coronary artery disease and stroke. It is also related to a reduced capacity for exercise, but the underlying mechanism is only partially understood. There are several factors that contribute to the development of skeletal muscle dysfunction, of which oxidative stress and mitochondrial dysfunction are among the most important. This review discusses the role of oxidative stress in the development and progression of skeletal and cardiac dysfunction associated with diabetes. It also provides an overview of the potential actions of antioxidants in general and mitochondria-targeted antioxidants in particular in the treatment of muscle dysfunction in type 2 diabetes.

KW - Antioxidants

KW - Mitochondria

KW - Muscle

KW - Oxidative stress

KW - Type 2 diabetes

UR - https://www.scopus.com/pages/publications/84974686206

U2 - 10.2174/1381612822666160217142949

DO - 10.2174/1381612822666160217142949

M3 - Article

C2 - 26898744

AN - SCOPUS:84974686206

SN - 1381-6128

VL - 22

SP - 2650

EP - 2656

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

IS - 18

ER -

Role of oxidative stress and mitochondrial dysfunction in skeletal muscle in type 2 diabetic patients

Abstract

Keywords

UN SDGs

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