TY - JOUR
T1 - Role of serotonergic-related systems in suicidal behavior
T2 - Data from a case-control association study
AU - Saiz, Pilar A.
AU - García-Portilla, Paz
AU - Paredes, Begoña
AU - Corcoran, Paul
AU - Arango, Celso
AU - Morales, Blanca
AU - Sotomayor, Emilio
AU - Alvarez, Victoria
AU - Coto, Eliecer
AU - Flórez, Gerardo
AU - Bascaran, María Teresa
AU - Bousoño, Manuel
AU - Bobes, Julio
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Objective: To investigate whether functional polymorphisms directly (HTR2A and SLC6A4 genes) or indirectly (IL-1 gene complex, APOE and ACE genes) related with serotonergic neurotransmission were associated with suicidal behavior. Subjects and methods: 227 suicide attempters, 686 non-suicidal psychiatric patients, and 420 healthy controls from a homogeneous Spanish Caucasian population were genotyped using standard methods. Results: There were no differences in genotype frequencies between the three groups. The -1438A/G [- 2 (df)=9.80 (2), uncorrected p=0.007] and IL-1- -889C/T [- 2 (df)=8.76 (2), uncorrected p=0.013] genotype frequencies between impulsive and planned suicide attempts trended toward being different (not significant after Bonferroni correction). Suicide attempts were more often impulsive in the presence of -1438G/G or IL-1α -889C/T or C/C genotypes. There was interaction between the polymorphism 5-HTTLPR and age [LRT (df)=6.84 (2), p=0.033] and between the polymorphisms APOE and IL-1RA (86bp) n [LRT (df)=12.21 (4), p=0.016] in relation to suicide attempt lethality. Conclusion: These findings further evidence the complexity of the association between genetics and suicidal behavior, the need to study homogenous forms of the behavior and the relevance of impulsive and aggressive traits as endophenotypes for suicidal behavior.
AB - Objective: To investigate whether functional polymorphisms directly (HTR2A and SLC6A4 genes) or indirectly (IL-1 gene complex, APOE and ACE genes) related with serotonergic neurotransmission were associated with suicidal behavior. Subjects and methods: 227 suicide attempters, 686 non-suicidal psychiatric patients, and 420 healthy controls from a homogeneous Spanish Caucasian population were genotyped using standard methods. Results: There were no differences in genotype frequencies between the three groups. The -1438A/G [- 2 (df)=9.80 (2), uncorrected p=0.007] and IL-1- -889C/T [- 2 (df)=8.76 (2), uncorrected p=0.013] genotype frequencies between impulsive and planned suicide attempts trended toward being different (not significant after Bonferroni correction). Suicide attempts were more often impulsive in the presence of -1438G/G or IL-1α -889C/T or C/C genotypes. There was interaction between the polymorphism 5-HTTLPR and age [LRT (df)=6.84 (2), p=0.033] and between the polymorphisms APOE and IL-1RA (86bp) n [LRT (df)=12.21 (4), p=0.016] in relation to suicide attempt lethality. Conclusion: These findings further evidence the complexity of the association between genetics and suicidal behavior, the need to study homogenous forms of the behavior and the relevance of impulsive and aggressive traits as endophenotypes for suicidal behavior.
KW - Angiotensin converting enzyme
KW - Apolipoprotein E
KW - Interleukin-1 gene complex
KW - Serotonin system
KW - Suicidal behavior
UR - https://www.scopus.com/pages/publications/79960461580
U2 - 10.1016/j.pnpbp.2011.04.011
DO - 10.1016/j.pnpbp.2011.04.011
M3 - Article
C2 - 21575667
AN - SCOPUS:79960461580
SN - 0278-5846
VL - 35
SP - 1518
EP - 1524
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 6
ER -
