Rule-in thresholds for DELFIA Xpress PlGF 1-2-3 test for suspected pre-eclampsia

Lucie Giblin; Fergus P. McCarthy; Carolyn Gill; Paul T. Seed; Kate Bramham; Anna Brockbank; Lucy C. Chappell; Andrew H. Shennan

doi:10.1016/j.preghy.2020.04.005

Rule-in thresholds for DELFIA Xpress PlGF 1-2-3 test for suspected pre-eclampsia

Lucie Giblin
, Fergus P. McCarthy
, Carolyn Gill
, Paul T. Seed
, Kate Bramham
, Anna Brockbank
, Lucy C. Chappell
, Andrew H. Shennan

St Thomas' Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

We aimed to establish a rule-in threshold for the DELFIA Xpress placental growth factor (PlGF) 1-2-3 test. Plasma EDTA samples from 305 women presenting with suspected pre-eclampsia before 35 weeks’ gestation were analysed using three different PlGF-based tests: PlGF 1-2-3 test (Perkin Elmer); Triage PlGF test (Quidel); Elecsys immunoassay sFlt-1/PlGF ratio (Roche). The rule-in threshold for PlGF 1-2-3 test created with equivalent specificity of the Quidel and Roche tests was 50 pg/ml. This can be used as a rule-in test for diagnosis of preterm pre-eclampsia requiring delivery within 14 days (specificity 95.0% (95% CI 91.7–97.2%), positive predictive value 50 (95% CI 30.6–69.4%), positive likelihood ratio 10.7 (5.8–20).

Original language	English
Pages (from-to)	35-37
Number of pages	3
Journal	Pregnancy Hypertension
Volume	21
DOIs	https://doi.org/10.1016/j.preghy.2020.04.005
Publication status	Published - Jul 2020
Externally published	Yes

Keywords

Diagnostic
PlGF
Pre-eclampsia
Test performance

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10.1016/j.preghy.2020.04.005

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@article{89f12cf2e9394e459dafb6559e5a8364,

title = "Rule-in thresholds for DELFIA Xpress PlGF 1-2-3 test for suspected pre-eclampsia",

abstract = "We aimed to establish a rule-in threshold for the DELFIA Xpress placental growth factor (PlGF) 1-2-3 test. Plasma EDTA samples from 305 women presenting with suspected pre-eclampsia before 35 weeks{\textquoteright} gestation were analysed using three different PlGF-based tests: PlGF 1-2-3 test (Perkin Elmer); Triage PlGF test (Quidel); Elecsys immunoassay sFlt-1/PlGF ratio (Roche). The rule-in threshold for PlGF 1-2-3 test created with equivalent specificity of the Quidel and Roche tests was 50 pg/ml. This can be used as a rule-in test for diagnosis of preterm pre-eclampsia requiring delivery within 14 days (specificity 95.0\% (95\% CI 91.7–97.2\%), positive predictive value 50 (95\% CI 30.6–69.4\%), positive likelihood ratio 10.7 (5.8–20).",

keywords = "Diagnostic, PlGF, Pre-eclampsia, Test performance",

author = "Lucie Giblin and McCarthy, \{Fergus P.\} and Carolyn Gill and Seed, \{Paul T.\} and Kate Bramham and Anna Brockbank and Chappell, \{Lucy C.\} and Shennan, \{Andrew H.\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = jul,

doi = "10.1016/j.preghy.2020.04.005",

language = "English",

volume = "21",

pages = "35--37",

journal = "Pregnancy Hypertension",

issn = "2210-7789",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Rule-in thresholds for DELFIA Xpress PlGF 1-2-3 test for suspected pre-eclampsia

AU - Giblin, Lucie

AU - McCarthy, Fergus P.

AU - Gill, Carolyn

AU - Seed, Paul T.

AU - Bramham, Kate

AU - Brockbank, Anna

AU - Chappell, Lucy C.

AU - Shennan, Andrew H.

PY - 2020/7

Y1 - 2020/7

N2 - We aimed to establish a rule-in threshold for the DELFIA Xpress placental growth factor (PlGF) 1-2-3 test. Plasma EDTA samples from 305 women presenting with suspected pre-eclampsia before 35 weeks’ gestation were analysed using three different PlGF-based tests: PlGF 1-2-3 test (Perkin Elmer); Triage PlGF test (Quidel); Elecsys immunoassay sFlt-1/PlGF ratio (Roche). The rule-in threshold for PlGF 1-2-3 test created with equivalent specificity of the Quidel and Roche tests was 50 pg/ml. This can be used as a rule-in test for diagnosis of preterm pre-eclampsia requiring delivery within 14 days (specificity 95.0% (95% CI 91.7–97.2%), positive predictive value 50 (95% CI 30.6–69.4%), positive likelihood ratio 10.7 (5.8–20).

AB - We aimed to establish a rule-in threshold for the DELFIA Xpress placental growth factor (PlGF) 1-2-3 test. Plasma EDTA samples from 305 women presenting with suspected pre-eclampsia before 35 weeks’ gestation were analysed using three different PlGF-based tests: PlGF 1-2-3 test (Perkin Elmer); Triage PlGF test (Quidel); Elecsys immunoassay sFlt-1/PlGF ratio (Roche). The rule-in threshold for PlGF 1-2-3 test created with equivalent specificity of the Quidel and Roche tests was 50 pg/ml. This can be used as a rule-in test for diagnosis of preterm pre-eclampsia requiring delivery within 14 days (specificity 95.0% (95% CI 91.7–97.2%), positive predictive value 50 (95% CI 30.6–69.4%), positive likelihood ratio 10.7 (5.8–20).

KW - Diagnostic

KW - PlGF

KW - Pre-eclampsia

KW - Test performance

UR - https://www.scopus.com/pages/publications/85084207508

U2 - 10.1016/j.preghy.2020.04.005

DO - 10.1016/j.preghy.2020.04.005

M3 - Article

C2 - 32388118

AN - SCOPUS:85084207508

SN - 2210-7789

VL - 21

SP - 35

EP - 37

JO - Pregnancy Hypertension

JF - Pregnancy Hypertension

ER -

Rule-in thresholds for DELFIA Xpress PlGF 1-2-3 test for suspected pre-eclampsia

Abstract

Keywords

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