Saturable zinc uptake by syncytiotrophoblast microvillous plasma membrane vesicles from human placenta

Gerard Quinn; Albert  Flynn; B. Lönnerdal

doi:10.1007/978-1-4613-0723-5_146

Saturable zinc uptake by syncytiotrophoblast microvillous plasma membrane vesicles from human placenta

Gerard Quinn
, Albert Flynn
, B. Lönnerdal

School of Food and Nutritional Sciences

University College Cork

Research output: Chapter in Book/Report/Conference proceedings › Chapter

Abstract

An adequate supply of zinc is essential for normal fetal development. Zinc from maternal plasma is transported across placental membranes, but the mechanism is poorly understood. The syncytiotrophoblast microvillous plasma membrane is the effective primary interface between mother and fetus and vesicles prepared from this membrane constitute a relatively simple experimental system for investigating the uptake of zinc from maternal plasma into the syncytiotrophoblast without interference from the subsequent stages of transport through the cell to the fetal plasma (Flynn et al., 1986). The aim of this study was to investigate the kinetics of zinc uptake by these vesicles.

Original language	English (Ireland)
Title of host publication	Trace Elements in Man & Animals - 6
Editors	L. S. Hurley, C. L. Keen, B. Lönnerdal, R. B. Rucker
Place of Publication	New York
Publisher	Plenum Publishers
Pages	425-426
ISBN (Electronic)	978-1-4613-0723-5
ISBN (Print)	978-1-4612-8050-7
DOIs	https://doi.org/10.1007/978-1-4613-0723-5_146
Publication status	Published - 1988

Keywords

zinc concentration
HEPES buffer
human placenta
maternal plasma
zinc uptake

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10.1007/978-1-4613-0723-5_146

Cite this

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title = "Saturable zinc uptake by syncytiotrophoblast microvillous plasma membrane vesicles from human placenta",

abstract = "An adequate supply of zinc is essential for normal fetal development. Zinc from maternal plasma is transported across placental membranes, but the mechanism is poorly understood. The syncytiotrophoblast microvillous plasma membrane is the effective primary interface between mother and fetus and vesicles prepared from this membrane constitute a relatively simple experimental system for investigating the uptake of zinc from maternal plasma into the syncytiotrophoblast without interference from the subsequent stages of transport through the cell to the fetal plasma (Flynn et al., 1986). The aim of this study was to investigate the kinetics of zinc uptake by these vesicles.",

keywords = "zinc concentration, HEPES buffer, human placenta, maternal plasma, zinc uptake",

author = "Gerard Quinn and Albert Flynn and B. L{\"o}nnerdal",

year = "1988",

doi = "10.1007/978-1-4613-0723-5\_146",

language = "English (Ireland)",

isbn = "978-1-4612-8050-7",

pages = "425--426",

editor = "Hurley, \{L. S.\} and Keen, \{C. L.\} and B. L{\"o}nnerdal and Rucker, \{R. B.\}",

booktitle = "Trace Elements in Man \& Animals - 6",

publisher = "Plenum Publishers",

address = "United States",

}

Saturable zinc uptake by syncytiotrophoblast microvillous plasma membrane vesicles from human placenta. / Quinn, Gerard; Flynn, Albert ; Lönnerdal, B.
Trace Elements in Man & Animals - 6. ed. / L. S. Hurley; C. L. Keen; B. Lönnerdal; R. B. Rucker. New York: Plenum Publishers, 1988. p. 425-426.

Research output: Chapter in Book/Report/Conference proceedings › Chapter

TY - CHAP

T1 - Saturable zinc uptake by syncytiotrophoblast microvillous plasma membrane vesicles from human placenta

AU - Quinn, Gerard

AU - Flynn, Albert

AU - Lönnerdal, B.

PY - 1988

Y1 - 1988

N2 - An adequate supply of zinc is essential for normal fetal development. Zinc from maternal plasma is transported across placental membranes, but the mechanism is poorly understood. The syncytiotrophoblast microvillous plasma membrane is the effective primary interface between mother and fetus and vesicles prepared from this membrane constitute a relatively simple experimental system for investigating the uptake of zinc from maternal plasma into the syncytiotrophoblast without interference from the subsequent stages of transport through the cell to the fetal plasma (Flynn et al., 1986). The aim of this study was to investigate the kinetics of zinc uptake by these vesicles.

AB - An adequate supply of zinc is essential for normal fetal development. Zinc from maternal plasma is transported across placental membranes, but the mechanism is poorly understood. The syncytiotrophoblast microvillous plasma membrane is the effective primary interface between mother and fetus and vesicles prepared from this membrane constitute a relatively simple experimental system for investigating the uptake of zinc from maternal plasma into the syncytiotrophoblast without interference from the subsequent stages of transport through the cell to the fetal plasma (Flynn et al., 1986). The aim of this study was to investigate the kinetics of zinc uptake by these vesicles.

KW - zinc concentration

KW - HEPES buffer

KW - human placenta

KW - maternal plasma

KW - zinc uptake

U2 - 10.1007/978-1-4613-0723-5_146

DO - 10.1007/978-1-4613-0723-5_146

M3 - Chapter

SN - 978-1-4612-8050-7

SP - 425

EP - 426

BT - Trace Elements in Man & Animals - 6

A2 - Hurley, L. S.

A2 - Keen, C. L.

A2 - Lönnerdal, B.

A2 - Rucker, R. B.

PB - Plenum Publishers

CY - New York

ER -

Saturable zinc uptake by syncytiotrophoblast microvillous plasma membrane vesicles from human placenta

Abstract

Keywords

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