Seasonality, parasite diversity, and local extinctions in Plasmodium falciparum malaria

F. Ellis McKenzie; Gerry F. Killeen; John C. Beier; William H. Bossert

doi:10.1890/0012-9658(2001)082[2673:spdale]2.0.co;2

Seasonality, parasite diversity, and local extinctions in Plasmodium falciparum malaria

F. Ellis McKenzie
, Gerry F. Killeen
, John C. Beier
, William H. Bossert

Research output: Contribution to journal › Article › peer-review

Abstract

We incorporate stochastic, density-dependent seasonal recruitment in adult Anopheles mosquito populations in a discrete-event model of Plasmodium falciparum malaria transmission and find the probabilities of parasite extinction higher than with perennial transmission. Seasonal fluctuations in vector populations act to synchronize the dynamics of infection and immunity in host populations, leading to fluctuations in parasite prevalence greater than expected solely on the basis of high- and low-season vector densities. This synchronization also biases frequencies of infection with multiple parasite phenotypes or genotypes.

Original language	English
Pages (from-to)	2673-2681
Number of pages	9
Journal	Ecology
Volume	82
Issue number	10
DOIs	https://doi.org/10.1890/0012-9658(2001)082[2673:spdale]2.0.co;2
Publication status	Published - 2001
Externally published	Yes

Keywords

Host
Infection
Local extinction
Malaria
Parasite
Seasonal
Transmission
Vector

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1890/0012-9658(2001)082[2673:spdale]2.0.co;2

Cite this

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title = "Seasonality, parasite diversity, and local extinctions in Plasmodium falciparum malaria",

abstract = "We incorporate stochastic, density-dependent seasonal recruitment in adult Anopheles mosquito populations in a discrete-event model of Plasmodium falciparum malaria transmission and find the probabilities of parasite extinction higher than with perennial transmission. Seasonal fluctuations in vector populations act to synchronize the dynamics of infection and immunity in host populations, leading to fluctuations in parasite prevalence greater than expected solely on the basis of high- and low-season vector densities. This synchronization also biases frequencies of infection with multiple parasite phenotypes or genotypes.",

keywords = "Host, Infection, Local extinction, Malaria, Parasite, Seasonal, Transmission, Vector",

author = "McKenzie, \{F. Ellis\} and Killeen, \{Gerry F.\} and Beier, \{John C.\} and Bossert, \{William H.\}",

year = "2001",

doi = "10.1890/0012-9658(2001)082[2673:spdale]2.0.co;2",

language = "English",

volume = "82",

pages = "2673--2681",

journal = "Ecology",

issn = "0012-9658",

publisher = "Ecological Society of America",

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TY - JOUR

T1 - Seasonality, parasite diversity, and local extinctions in Plasmodium falciparum malaria

AU - McKenzie, F. Ellis

AU - Killeen, Gerry F.

AU - Beier, John C.

AU - Bossert, William H.

PY - 2001

Y1 - 2001

N2 - We incorporate stochastic, density-dependent seasonal recruitment in adult Anopheles mosquito populations in a discrete-event model of Plasmodium falciparum malaria transmission and find the probabilities of parasite extinction higher than with perennial transmission. Seasonal fluctuations in vector populations act to synchronize the dynamics of infection and immunity in host populations, leading to fluctuations in parasite prevalence greater than expected solely on the basis of high- and low-season vector densities. This synchronization also biases frequencies of infection with multiple parasite phenotypes or genotypes.

AB - We incorporate stochastic, density-dependent seasonal recruitment in adult Anopheles mosquito populations in a discrete-event model of Plasmodium falciparum malaria transmission and find the probabilities of parasite extinction higher than with perennial transmission. Seasonal fluctuations in vector populations act to synchronize the dynamics of infection and immunity in host populations, leading to fluctuations in parasite prevalence greater than expected solely on the basis of high- and low-season vector densities. This synchronization also biases frequencies of infection with multiple parasite phenotypes or genotypes.

KW - Host

KW - Infection

KW - Local extinction

KW - Malaria

KW - Parasite

KW - Seasonal

KW - Transmission

KW - Vector

UR - https://www.scopus.com/pages/publications/0034761219

U2 - 10.1890/0012-9658(2001)082[2673:spdale]2.0.co;2

DO - 10.1890/0012-9658(2001)082[2673:spdale]2.0.co;2

M3 - Article

AN - SCOPUS:0034761219

SN - 0012-9658

VL - 82

SP - 2673

EP - 2681

JO - Ecology

JF - Ecology

IS - 10

ER -

Seasonality, parasite diversity, and local extinctions in Plasmodium falciparum malaria

Abstract

Keywords

UN SDGs

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