Abstract
Background: Selenium (Se) is a trace element active in selenoproteins, which can regulate oxidative stress. It is generally perceived as an import factor for maintaining health in the elderly. Methods: The goal of this review is to discuss selenium concentration in biological samples, primarily serum or plasma, as a function of age and its relation with longevity. The elemental level in various age-related diseases is reviewed. Conclusion: Highest selenium values were observed in healthy adults, while in an elderly population significantly lower concentrations were reported. Variables responsible for contradictory findings are mentioned. Risk and benefits of Se-supplementation still remain under debate.
| Original language | English |
|---|---|
| Pages (from-to) | 1694-1706 |
| Number of pages | 13 |
| Journal | Current Pharmaceutical Design |
| Volume | 25 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- Age-related diseases
- Biological materials
- Longevity
- Oxidative stress
- Se-supplementation
- Selenium