Silicon-based surface plasmon resonance biosensor

S. Patskovsky; A. V. Kabashin; M. Meunier; J. H.T. Luong

doi:10.1117/12.2283906

Silicon-based surface plasmon resonance biosensor

S. Patskovsky
, A. V. Kabashin
, M. Meunier
, J. H.T. Luong

Research output: Contribution to journal › Article › peer-review

Abstract

Surface Plasmon Resonance (SPR) has been considered as a leading instrumentation for direct, label-free detection of recognition and binding events between a target analyte (antigens, hormones, DNAs, etc.) and its corresponding receptor (antibodies, capture probe DNA, proteins etc.) immobilized to the surface/liquid interface. Conventional SPR systems are based on a glass technology, in which p-polarized light, is directed through a glass prism and reflected from a gold film deposited on the prism surface. SPR effect causes a dip in angular (wavelength) dependence of the reflected light intensity with the resulting position extremely sensitive to the refractive index and the thickness of the thin biolayer. This remarkable property has been employed towards the development of SPR- based biosensors1'2, for real-time characterization of biological interactions on the gold surface (for review, see, e.g. Ref. 3).

Original language	English
Article number	1031332
Pages (from-to)	299-301
Number of pages	3
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	10313
DOIs	https://doi.org/10.1117/12.2283906
Publication status	Published - 9 May 2002
Externally published	Yes
Event	SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, Opto-Canada 2002 - Ottawa, Canada Duration: 9 May 2002 → 10 May 2002

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title = "Silicon-based surface plasmon resonance biosensor",

abstract = "Surface Plasmon Resonance (SPR) has been considered as a leading instrumentation for direct, label-free detection of recognition and binding events between a target analyte (antigens, hormones, DNAs, etc.) and its corresponding receptor (antibodies, capture probe DNA, proteins etc.) immobilized to the surface/liquid interface. Conventional SPR systems are based on a glass technology, in which p-polarized light, is directed through a glass prism and reflected from a gold film deposited on the prism surface. SPR effect causes a dip in angular (wavelength) dependence of the reflected light intensity with the resulting position extremely sensitive to the refractive index and the thickness of the thin biolayer. This remarkable property has been employed towards the development of SPR- based biosensors1'2, for real-time characterization of biological interactions on the gold surface (for review, see, e.g. Ref. 3).",

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doi = "10.1117/12.2283906",

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T1 - Silicon-based surface plasmon resonance biosensor

AU - Patskovsky, S.

AU - Kabashin, A. V.

AU - Meunier, M.

AU - Luong, J. H.T.

PY - 2002/5/9

Y1 - 2002/5/9

N2 - Surface Plasmon Resonance (SPR) has been considered as a leading instrumentation for direct, label-free detection of recognition and binding events between a target analyte (antigens, hormones, DNAs, etc.) and its corresponding receptor (antibodies, capture probe DNA, proteins etc.) immobilized to the surface/liquid interface. Conventional SPR systems are based on a glass technology, in which p-polarized light, is directed through a glass prism and reflected from a gold film deposited on the prism surface. SPR effect causes a dip in angular (wavelength) dependence of the reflected light intensity with the resulting position extremely sensitive to the refractive index and the thickness of the thin biolayer. This remarkable property has been employed towards the development of SPR- based biosensors1'2, for real-time characterization of biological interactions on the gold surface (for review, see, e.g. Ref. 3).

AB - Surface Plasmon Resonance (SPR) has been considered as a leading instrumentation for direct, label-free detection of recognition and binding events between a target analyte (antigens, hormones, DNAs, etc.) and its corresponding receptor (antibodies, capture probe DNA, proteins etc.) immobilized to the surface/liquid interface. Conventional SPR systems are based on a glass technology, in which p-polarized light, is directed through a glass prism and reflected from a gold film deposited on the prism surface. SPR effect causes a dip in angular (wavelength) dependence of the reflected light intensity with the resulting position extremely sensitive to the refractive index and the thickness of the thin biolayer. This remarkable property has been employed towards the development of SPR- based biosensors1'2, for real-time characterization of biological interactions on the gold surface (for review, see, e.g. Ref. 3).

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Y2 - 9 May 2002 through 10 May 2002

ER -

Silicon-based surface plasmon resonance biosensor

Abstract

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