TY - JOUR
T1 - Silicon photonics-based laser Doppler vibrometer array for carotid-femoral pulse wave velocity (PWV) measurement
AU - LI, YANLU
AU - MARAIS, LOUISE
AU - KHETTAB, HAKIM
AU - QUAN, ZHIHENG
AU - AASMUL, SOREN
AU - LEINDERS, ROB
AU - SCHÜLER, RALF
AU - MORRISSEY, PADRAIC E.
AU - GREENWALD, STEPHEN
AU - SEGERS, PATRICK
AU - VANSLEMBROUCK, MICHAEL
AU - BRUNO, ROSA M.
AU - BOUTOUYRIE, PIERRE
AU - O'BRIEN, PETER
AU - DE MELIS, MIRKO
AU - BAETS, ROEL
N1 - Publisher Copyright:
© 2020 Optical Society of America.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Pulse wave velocity (PWV) is a reference measure for aortic stiffness, itself an important biomarker of cardiovascular risk. To enable low-cost and easy-to-use PWV measurement devices that can be used in routine clinical practice, we have designed several handheld PWV sensors using miniaturized laser Doppler vibrometer (LDV) arrays in a silicon photonics platform. The LDV-based PWV sensor design and the signal processing protocol to obtain pulse transit time (PTT) and carotid-femoral PWV in a feasibility study in humans, are described in this paper. Compared with a commercial reference PWV measurement system, measuring arterial pressure waveforms by applanation tonometry, LDV-based displacement signals resulted in more complex signals. However, we have shown that it is possible to identify reliable fiducial points for PTT calculation using the maximum of the 2nd derivative algorithm in LDV-based signals, comparableto those obtained by the reference technique, applanation tonometry.
AB - Pulse wave velocity (PWV) is a reference measure for aortic stiffness, itself an important biomarker of cardiovascular risk. To enable low-cost and easy-to-use PWV measurement devices that can be used in routine clinical practice, we have designed several handheld PWV sensors using miniaturized laser Doppler vibrometer (LDV) arrays in a silicon photonics platform. The LDV-based PWV sensor design and the signal processing protocol to obtain pulse transit time (PTT) and carotid-femoral PWV in a feasibility study in humans, are described in this paper. Compared with a commercial reference PWV measurement system, measuring arterial pressure waveforms by applanation tonometry, LDV-based displacement signals resulted in more complex signals. However, we have shown that it is possible to identify reliable fiducial points for PTT calculation using the maximum of the 2nd derivative algorithm in LDV-based signals, comparableto those obtained by the reference technique, applanation tonometry.
UR - https://www.scopus.com/pages/publications/85087957832
U2 - 10.1364/BOE.394921
DO - 10.1364/BOE.394921
M3 - Article
AN - SCOPUS:85087957832
SN - 2156-7085
VL - 11
SP - 3913
EP - 3926
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 7
ER -