STC-1 cells

Triona Mc Carthy; Brian D. Green; Danielle Calderwood; Anna Gillespie; John F. Cryan; Linda Giblin

doi:10.1007/978-3-319-16104-4_19

STC-1 cells

Triona Mc Carthy
, Brian D. Green
, Danielle Calderwood
, Anna Gillespie
, John F. Cryan
, Linda Giblin

Research output: Chapter in Book/Report/Conference proceedings › Chapter › peer-review

Abstract

Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and peptide YY (PYY) play an important role in suppressing hunger and controlling food intake. These satiety hormones are secreted from enteroendocrine cells present throughout the intestinal tract. The intestinal secretin tumor cell line (STC-1) possesses many features of native intestinal enteroendocrine cells. As such, STC-1 cells are routinely used in screening platforms to identify foods or compounds that modulate secretion of gastrointestinal hormones in vitro. This chapter describes this intestinal cell model focussing on it’s applications, advantages and limitations. A general protocol is provided for challenging STC-1 cells with test compounds.

Original language	English
Title of host publication	The Impact of Food Bioactives on Health
Subtitle of host publication	In Vitro and Ex Vivo Models
Publisher	Springer International Publishing
Pages	211-220
Number of pages	10
ISBN (Electronic)	9783319161044
ISBN (Print)	9783319157917
DOIs	https://doi.org/10.1007/978-3-319-16104-4_19
Publication status	Published - 1 Jan 2015

Keywords

CCK
Enteroendocrine cells
Food components
G protein coupled receptors
GLP-1
Nutrient sensing
PYY
Satiety hormones
Secretin tumor cell line (STC-1)

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10.1007/978-3-319-16104-4_19

Cite this

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abstract = "Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and peptide YY (PYY) play an important role in suppressing hunger and controlling food intake. These satiety hormones are secreted from enteroendocrine cells present throughout the intestinal tract. The intestinal secretin tumor cell line (STC-1) possesses many features of native intestinal enteroendocrine cells. As such, STC-1 cells are routinely used in screening platforms to identify foods or compounds that modulate secretion of gastrointestinal hormones in vitro. This chapter describes this intestinal cell model focussing on it{\textquoteright}s applications, advantages and limitations. A general protocol is provided for challenging STC-1 cells with test compounds.",

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AU - Mc Carthy, Triona

AU - Green, Brian D.

AU - Calderwood, Danielle

AU - Gillespie, Anna

AU - Cryan, John F.

AU - Giblin, Linda

N1 - Publisher Copyright: © The Editor(s) (if applicable) and the Author(s) 2015.

PY - 2015/1/1

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N2 - Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and peptide YY (PYY) play an important role in suppressing hunger and controlling food intake. These satiety hormones are secreted from enteroendocrine cells present throughout the intestinal tract. The intestinal secretin tumor cell line (STC-1) possesses many features of native intestinal enteroendocrine cells. As such, STC-1 cells are routinely used in screening platforms to identify foods or compounds that modulate secretion of gastrointestinal hormones in vitro. This chapter describes this intestinal cell model focussing on it’s applications, advantages and limitations. A general protocol is provided for challenging STC-1 cells with test compounds.

AB - Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and peptide YY (PYY) play an important role in suppressing hunger and controlling food intake. These satiety hormones are secreted from enteroendocrine cells present throughout the intestinal tract. The intestinal secretin tumor cell line (STC-1) possesses many features of native intestinal enteroendocrine cells. As such, STC-1 cells are routinely used in screening platforms to identify foods or compounds that modulate secretion of gastrointestinal hormones in vitro. This chapter describes this intestinal cell model focussing on it’s applications, advantages and limitations. A general protocol is provided for challenging STC-1 cells with test compounds.

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KW - Enteroendocrine cells

KW - Food components

KW - G protein coupled receptors

KW - GLP-1

KW - Nutrient sensing

KW - PYY

KW - Satiety hormones

KW - Secretin tumor cell line (STC-1)

UR - https://www.scopus.com/pages/publications/84945156687

U2 - 10.1007/978-3-319-16104-4_19

DO - 10.1007/978-3-319-16104-4_19

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AN - SCOPUS:84945156687

SN - 9783319157917

SP - 211

EP - 220

BT - The Impact of Food Bioactives on Health

PB - Springer International Publishing

ER -

STC-1 cells

Abstract

Keywords

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