Structure of the chromosomal chicken progesterone receptor gene.

C. S. Huckaby; O. M. Conneely; W. G. Beattie; A. D. Dobson; M. J. Tsai; B. W. O'Malley

doi:10.1073/pnas.84.23.8380

Structure of the chromosomal chicken progesterone receptor gene.

C. S. Huckaby
, O. M. Conneely
, W. G. Beattie
, A. D. Dobson
, M. J. Tsai
, B. W. O'Malley

Baylor College of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We have isolated cosmid clones containing the chromosomal chicken progesterone receptor gene. The gene consists of eight exons and is approximately 38 kilobases long. Individual exons correlate well with conserved functional domains of the receptor molecule. Alternative polyadenylylation in the second intron results in a putative non-hormone-binding protein. The cap site of the gene is heterogeneous over at least 14 base pairs and lies in a very G + C-rich region. The promoter lacks "TATA" and "CAAT" boxes, but CCGCCC motifs exist in the surrounding region.

Original language	English
Pages (from-to)	8380-8384
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	84
Issue number	23
DOIs	https://doi.org/10.1073/pnas.84.23.8380
Publication status	Published - Dec 1987
Externally published	Yes

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title = "Structure of the chromosomal chicken progesterone receptor gene.",

abstract = "We have isolated cosmid clones containing the chromosomal chicken progesterone receptor gene. The gene consists of eight exons and is approximately 38 kilobases long. Individual exons correlate well with conserved functional domains of the receptor molecule. Alternative polyadenylylation in the second intron results in a putative non-hormone-binding protein. The cap site of the gene is heterogeneous over at least 14 base pairs and lies in a very G + C-rich region. The promoter lacks {"}TATA{"} and {"}CAAT{"} boxes, but CCGCCC motifs exist in the surrounding region.",

author = "Huckaby, \{C. S.\} and Conneely, \{O. M.\} and Beattie, \{W. G.\} and Dobson, \{A. D.\} and Tsai, \{M. J.\} and O'Malley, \{B. W.\}",

year = "1987",

month = dec,

doi = "10.1073/pnas.84.23.8380",

language = "English",

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T1 - Structure of the chromosomal chicken progesterone receptor gene.

AU - Huckaby, C. S.

AU - Conneely, O. M.

AU - Beattie, W. G.

AU - Dobson, A. D.

AU - Tsai, M. J.

AU - O'Malley, B. W.

PY - 1987/12

Y1 - 1987/12

N2 - We have isolated cosmid clones containing the chromosomal chicken progesterone receptor gene. The gene consists of eight exons and is approximately 38 kilobases long. Individual exons correlate well with conserved functional domains of the receptor molecule. Alternative polyadenylylation in the second intron results in a putative non-hormone-binding protein. The cap site of the gene is heterogeneous over at least 14 base pairs and lies in a very G + C-rich region. The promoter lacks "TATA" and "CAAT" boxes, but CCGCCC motifs exist in the surrounding region.

AB - We have isolated cosmid clones containing the chromosomal chicken progesterone receptor gene. The gene consists of eight exons and is approximately 38 kilobases long. Individual exons correlate well with conserved functional domains of the receptor molecule. Alternative polyadenylylation in the second intron results in a putative non-hormone-binding protein. The cap site of the gene is heterogeneous over at least 14 base pairs and lies in a very G + C-rich region. The promoter lacks "TATA" and "CAAT" boxes, but CCGCCC motifs exist in the surrounding region.

UR - https://www.scopus.com/pages/publications/0023495517

U2 - 10.1073/pnas.84.23.8380

DO - 10.1073/pnas.84.23.8380

M3 - Article

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AN - SCOPUS:0023495517

SN - 0027-8424

VL - 84

SP - 8380

EP - 8384

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 23

ER -

Structure of the chromosomal chicken progesterone receptor gene.

Abstract

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