Substrate inhibition kinetics for microbial growth and synthesis of poly-β-hydroxybutyric acid by Alcaligenes eutrophus ATCC 17697

A. Mulchandani; J. H.T. Luong; C. Groom

doi:10.1007/BF00255990

Substrate inhibition kinetics for microbial growth and synthesis of poly-β-hydroxybutyric acid by Alcaligenes eutrophus ATCC 17697

A. Mulchandani
, J. H.T. Luong
, C. Groom

National Research Council of Canada

Research output: Contribution to journal › Article › peer-review

Abstract

The specific growth rate of Alcaligenes eutrophus ATCC 17697 was observed to depend upon the ratio of ammonium sulfate (nitrogen) and fructose (carbon) concentration used for production of poly-β-hydroxybutyric acid (PHB). The growth rate was stimulated at low concentration ratios and inhibited at higher ratios. A mathematical expression was then proposed to fit the substrate inhibition kinetics: {Mathematical expression} Together with the Luedeking-Piret product formation equation, the proposed model describes the experimental data as well as literature data, for substrate consumption, growth of A. eutrophus, and poly-β-hydroxybutyric acid formation.

Original language	English
Pages (from-to)	11-17
Number of pages	7
Journal	Applied Microbiology and Biotechnology
Volume	30
Issue number	1
DOIs	https://doi.org/10.1007/BF00255990
Publication status	Published - Jan 1989
Externally published	Yes

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abstract = "The specific growth rate of Alcaligenes eutrophus ATCC 17697 was observed to depend upon the ratio of ammonium sulfate (nitrogen) and fructose (carbon) concentration used for production of poly-β-hydroxybutyric acid (PHB). The growth rate was stimulated at low concentration ratios and inhibited at higher ratios. A mathematical expression was then proposed to fit the substrate inhibition kinetics: \{Mathematical expression\} Together with the Luedeking-Piret product formation equation, the proposed model describes the experimental data as well as literature data, for substrate consumption, growth of A. eutrophus, and poly-β-hydroxybutyric acid formation.",

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AU - Luong, J. H.T.

AU - Groom, C.

PY - 1989/1

Y1 - 1989/1

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AB - The specific growth rate of Alcaligenes eutrophus ATCC 17697 was observed to depend upon the ratio of ammonium sulfate (nitrogen) and fructose (carbon) concentration used for production of poly-β-hydroxybutyric acid (PHB). The growth rate was stimulated at low concentration ratios and inhibited at higher ratios. A mathematical expression was then proposed to fit the substrate inhibition kinetics: {Mathematical expression} Together with the Luedeking-Piret product formation equation, the proposed model describes the experimental data as well as literature data, for substrate consumption, growth of A. eutrophus, and poly-β-hydroxybutyric acid formation.

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Substrate inhibition kinetics for microbial growth and synthesis of poly-β-hydroxybutyric acid by Alcaligenes eutrophus ATCC 17697

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