Sulfoxides: Potent co-crystal formers

Kevin S. Eccles; Curtis J. Elcoate; Stephen P. Stokes; Anita R. Maguire; Simon E. Lawrence

doi:10.1021/cg1010192

Sulfoxides: Potent co-crystal formers

Kevin S. Eccles
, Curtis J. Elcoate
, Stephen P. Stokes
, Anita R. Maguire
, Simon E. Lawrence

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

The design of co-crystals requires knowledge of robust supramolecular synthons. The sulfoxide is a potent hydrogen bond acceptor and has been used as a co-crystal former with a range of NH functional groups, via N-H⋯O S hydrogen bonds. The NH functional group retains favorable hydrogen bond motifs from its own structure in all cases where this is possible, with the sulfoxide interacting in a discrete, capping fashion in four cases and in a bifurcated, bridging fashion in the three other cases presented here.

Original language	English
Pages (from-to)	4243-4245
Number of pages	3
Journal	Crystal Growth and Design
Volume	10
Issue number	10
DOIs	https://doi.org/10.1021/cg1010192
Publication status	Published - 6 Oct 2010

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https://hdl.handle.net/10468/1420Licence: CC BY-NC-ND

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title = "Sulfoxides: Potent co-crystal formers",

abstract = "The design of co-crystals requires knowledge of robust supramolecular synthons. The sulfoxide is a potent hydrogen bond acceptor and has been used as a co-crystal former with a range of NH functional groups, via N-H⋯O S hydrogen bonds. The NH functional group retains favorable hydrogen bond motifs from its own structure in all cases where this is possible, with the sulfoxide interacting in a discrete, capping fashion in four cases and in a bifurcated, bridging fashion in the three other cases presented here.",

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T1 - Sulfoxides

T2 - Potent co-crystal formers

AU - Eccles, Kevin S.

AU - Elcoate, Curtis J.

AU - Stokes, Stephen P.

AU - Maguire, Anita R.

AU - Lawrence, Simon E.

PY - 2010/10/6

Y1 - 2010/10/6

N2 - The design of co-crystals requires knowledge of robust supramolecular synthons. The sulfoxide is a potent hydrogen bond acceptor and has been used as a co-crystal former with a range of NH functional groups, via N-H⋯O S hydrogen bonds. The NH functional group retains favorable hydrogen bond motifs from its own structure in all cases where this is possible, with the sulfoxide interacting in a discrete, capping fashion in four cases and in a bifurcated, bridging fashion in the three other cases presented here.

AB - The design of co-crystals requires knowledge of robust supramolecular synthons. The sulfoxide is a potent hydrogen bond acceptor and has been used as a co-crystal former with a range of NH functional groups, via N-H⋯O S hydrogen bonds. The NH functional group retains favorable hydrogen bond motifs from its own structure in all cases where this is possible, with the sulfoxide interacting in a discrete, capping fashion in four cases and in a bifurcated, bridging fashion in the three other cases presented here.

UR - https://www.scopus.com/pages/publications/77957700301

U2 - 10.1021/cg1010192

DO - 10.1021/cg1010192

M3 - Article

AN - SCOPUS:77957700301

SN - 1528-7483

VL - 10

SP - 4243

EP - 4245

JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 10

ER -

Sulfoxides: Potent co-crystal formers

Abstract

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