Synchronous Cerebral Occlusive Vasculopathy and Chronic Histiocytic Intervillositis of the Placenta: Distant Associations of the APS

Clara McGurk; Brendan Fitzgerald; Noel Fanning; Michael Jansen; Keelin O'Donoghue; Daniel J Costello

doi:10.1212/WNL.0000000000214880

Synchronous Cerebral Occlusive Vasculopathy and Chronic Histiocytic Intervillositis of the Placenta: Distant Associations of the APS

Clara McGurk
, Brendan Fitzgerald
, Noel Fanning
, Michael Jansen
, Keelin O'Donoghue
, Daniel J Costello

School of Medicine

Cork University Hospital
Cork University Maternity Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

During her first pregnancy, a 39-year-old woman developed progressive clumsiness of both hands. She subsequently had a fetal death at 18 weeks of gestation. Placental examination revealed pathologic features of chronic histiocytic intervillositis (CHI), leading to placental insufficiency (Figure 1).

Original language	English
Article number	e214880
Pages (from-to)	e214880
Journal	Neurology
Volume	106
Issue number	9
DOIs	https://doi.org/10.1212/WNL.0000000000214880
Publication status	Published - 12 May 2026

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title = "Synchronous Cerebral Occlusive Vasculopathy and Chronic Histiocytic Intervillositis of the Placenta: Distant Associations of the APS",

abstract = "During her first pregnancy, a 39-year-old woman developed progressive clumsiness of both hands. She subsequently had a fetal death at 18 weeks of gestation. Placental examination revealed pathologic features of chronic histiocytic intervillositis (CHI), leading to placental insufficiency (Figure 1).",

author = "Clara McGurk and Brendan Fitzgerald and Noel Fanning and Michael Jansen and Keelin O'Donoghue and Costello, \{Daniel J\}",

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AU - Fanning, Noel

AU - Jansen, Michael

AU - O'Donoghue, Keelin

AU - Costello, Daniel J

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AB - During her first pregnancy, a 39-year-old woman developed progressive clumsiness of both hands. She subsequently had a fetal death at 18 weeks of gestation. Placental examination revealed pathologic features of chronic histiocytic intervillositis (CHI), leading to placental insufficiency (Figure 1).

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Synchronous Cerebral Occlusive Vasculopathy and Chronic Histiocytic Intervillositis of the Placenta: Distant Associations of the APS

Abstract

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