Synthesis and biological activity of the novel nitric oxide synthase inhibitor Nω′-hydroxy-Nω-methyl-L-arginine

Humphrey A. Moynihan; Stanley M. Roberts; Hazel Weldon; Graham H. Allcock; Erik E. Änggård; Timothy D. Warner

doi:10.1039/p19940000769

Synthesis and biological activity of the novel nitric oxide synthase inhibitor N^ω′-hydroxy-N^ω-methyl-L-arginine

Humphrey A. Moynihan
, Stanley M. Roberts
, Hazel Weldon
, Graham H. Allcock
, Erik E. Änggård
, Timothy D. Warner

Research output: Contribution to journal › Article › peer-review

Abstract

N^ω′-Hydroxy-N^ω-methyl-L-arginine has been synthesised in eight steps from N^δ-(benzyloxycarbonyl) L-ornithine and has been found to inhibit the biosynthesis of nitric oxide.

Original language	English
Pages (from-to)	769-771
Number of pages	3
Journal	Journal of the Chemical Society, Perkin Transactions 1
Issue number	7
DOIs	https://doi.org/10.1039/p19940000769
Publication status	Published - 1994
Externally published	Yes

Access to Document

10.1039/p19940000769

Cite this

@article{1ee633379f47464b90663dbeecdbdd44,

title = "Synthesis and biological activity of the novel nitric oxide synthase inhibitor Nω′-hydroxy-Nω-methyl-L-arginine",

abstract = "Nω′-Hydroxy-Nω-methyl-L-arginine has been synthesised in eight steps from Nδ-(benzyloxycarbonyl) L-ornithine and has been found to inhibit the biosynthesis of nitric oxide.",

author = "Moynihan, \{Humphrey A.\} and Roberts, \{Stanley M.\} and Hazel Weldon and Allcock, \{Graham H.\} and {\"A}ngg{\aa}rd, \{Erik E.\} and Warner, \{Timothy D.\}",

year = "1994",

doi = "10.1039/p19940000769",

language = "English",

pages = "769--771",

journal = "Journal of the Chemical Society, Perkin Transactions 1",

issn = "1472-7781",

publisher = "Chemical Society",

number = "7",

}

TY - JOUR

T1 - Synthesis and biological activity of the novel nitric oxide synthase inhibitor Nω′-hydroxy-Nω-methyl-L-arginine

AU - Moynihan, Humphrey A.

AU - Roberts, Stanley M.

AU - Weldon, Hazel

AU - Allcock, Graham H.

AU - Änggård, Erik E.

AU - Warner, Timothy D.

PY - 1994

Y1 - 1994

N2 - Nω′-Hydroxy-Nω-methyl-L-arginine has been synthesised in eight steps from Nδ-(benzyloxycarbonyl) L-ornithine and has been found to inhibit the biosynthesis of nitric oxide.

AB - Nω′-Hydroxy-Nω-methyl-L-arginine has been synthesised in eight steps from Nδ-(benzyloxycarbonyl) L-ornithine and has been found to inhibit the biosynthesis of nitric oxide.

UR - https://www.scopus.com/pages/publications/37049080140

U2 - 10.1039/p19940000769

DO - 10.1039/p19940000769

M3 - Article

AN - SCOPUS:37049080140

SN - 1472-7781

SP - 769

EP - 771

JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

IS - 7

ER -

Synthesis and biological activity of the novel nitric oxide synthase inhibitor N^ω′-hydroxy-N^ω-methyl-L-arginine

Abstract

Access to Document

Other files and links

Fingerprint

Cite this