Synthesis of fluorinated oxygen- and sulfur-containing heteroaromatics

The incorporation of fluorine into a target molecule may have a considerable impact on its reactivity, selectivity, biological activity and physical properties. This is especially true in medicinal chemistry where fluorine is often employed as a bioisostere of hydrogen and where many important drug compounds also feature heteroaromatic rings. This work complements existing reviews on the synthesis of fluorinated, aromatic heterocycles, with a focus on less common oxygen-containing heteroaromatics as well as their sulfur-based analogues.