Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction

Vydyula P. Kumar; Manoj K. Gupta; Conor Horgan; Timothy P. O'Sullivan

doi:10.1016/j.tetlet.2018.04.071

Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction

Vydyula P. Kumar
, Manoj K. Gupta
, Conor Horgan
, Timothy P. O'Sullivan

Research output: Contribution to journal › Article › peer-review

Abstract

The development of a concise synthesis of the quorum sensing molecule Diffusible Signal Factor is described. This route exploits an alkyne zipper reaction to form a key terminal alkyne intermediate. The chemistry outlined here may also be applied to the preparation of cis-unsaturated analogues of Diffusible Signal Factor.

Original language	English
Pages (from-to)	2193-2195
Number of pages	3
Journal	Tetrahedron Letters
Volume	59
Issue number	22
DOIs	https://doi.org/10.1016/j.tetlet.2018.04.071
Publication status	Published - 30 May 2018

Keywords

Alkyne zipper reaction
Diffusible Signal Factor
Partial hydrogenation

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10.1016/j.tetlet.2018.04.071

https://hdl.handle.net/10468/11747Licence: CC BY-NC-ND

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title = "Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction",

abstract = "The development of a concise synthesis of the quorum sensing molecule Diffusible Signal Factor is described. This route exploits an alkyne zipper reaction to form a key terminal alkyne intermediate. The chemistry outlined here may also be applied to the preparation of cis-unsaturated analogues of Diffusible Signal Factor.",

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AU - O'Sullivan, Timothy P.

PY - 2018/5/30

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AB - The development of a concise synthesis of the quorum sensing molecule Diffusible Signal Factor is described. This route exploits an alkyne zipper reaction to form a key terminal alkyne intermediate. The chemistry outlined here may also be applied to the preparation of cis-unsaturated analogues of Diffusible Signal Factor.

KW - Alkyne zipper reaction

KW - Diffusible Signal Factor

KW - Partial hydrogenation

UR - https://www.scopus.com/pages/publications/85046345869

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Synthesis of the quorum sensing molecule Diffusible Signal Factor using the alkyne zipper reaction

Abstract

Keywords

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