Systematic review of neonatal seizure management strategies provides guidance on anti-epileptic treatment

Lena Hellström-Westas; Geraldine Boylan; Johan Ågren

doi:10.1111/apa.12812

Systematic review of neonatal seizure management strategies provides guidance on anti-epileptic treatment

Lena Hellström-Westas
, Geraldine Boylan
, Johan Ågren

Uppsala University

Research output: Contribution to journal › Review article › peer-review

Abstract

There is a lack of scientific evidence to support the best management of neonatal seizures. Current strategies for neonatal seizure management were investigated by analysis of all surveys published during the time period 2000-2012. Methods for seizure diagnosis and availability of electroencephalogram (EEG), including monitoring, varied. Phenobarbital was the drug of first choice, and the use of off-label drugs and treatment times varied. Conclusion: We conclude that there is an urgent need for more evidence-based studies to guide neonatal seizure management.

Original language	English
Pages (from-to)	123-129
Number of pages	7
Journal	Acta Paediatrica, International Journal of Paediatrics
Volume	104
Issue number	2
DOIs	https://doi.org/10.1111/apa.12812
Publication status	Published - 1 Feb 2015

Keywords

Anti-epileptic drugs
Electroencephalogram
Newborn
Phenobarbital
Status epilepticus

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10.1111/apa.12812

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title = "Systematic review of neonatal seizure management strategies provides guidance on anti-epileptic treatment",

abstract = "There is a lack of scientific evidence to support the best management of neonatal seizures. Current strategies for neonatal seizure management were investigated by analysis of all surveys published during the time period 2000-2012. Methods for seizure diagnosis and availability of electroencephalogram (EEG), including monitoring, varied. Phenobarbital was the drug of first choice, and the use of off-label drugs and treatment times varied. Conclusion: We conclude that there is an urgent need for more evidence-based studies to guide neonatal seizure management.",

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AU - Ågren, Johan

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N2 - There is a lack of scientific evidence to support the best management of neonatal seizures. Current strategies for neonatal seizure management were investigated by analysis of all surveys published during the time period 2000-2012. Methods for seizure diagnosis and availability of electroencephalogram (EEG), including monitoring, varied. Phenobarbital was the drug of first choice, and the use of off-label drugs and treatment times varied. Conclusion: We conclude that there is an urgent need for more evidence-based studies to guide neonatal seizure management.

AB - There is a lack of scientific evidence to support the best management of neonatal seizures. Current strategies for neonatal seizure management were investigated by analysis of all surveys published during the time period 2000-2012. Methods for seizure diagnosis and availability of electroencephalogram (EEG), including monitoring, varied. Phenobarbital was the drug of first choice, and the use of off-label drugs and treatment times varied. Conclusion: We conclude that there is an urgent need for more evidence-based studies to guide neonatal seizure management.

KW - Anti-epileptic drugs

KW - Electroencephalogram

KW - Newborn

KW - Phenobarbital

KW - Status epilepticus

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JF - Acta Paediatrica, International Journal of Paediatrics

IS - 2

ER -

Systematic review of neonatal seizure management strategies provides guidance on anti-epileptic treatment

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Keywords

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