TY - JOUR
T1 - Targeted Drug Delivery via Folate Receptors for the Treatment of Brain Cancer
T2 - Can the Promise Deliver?
AU - Guo, Jianfeng
AU - Schlich, Michele
AU - Cryan, John F.
AU - O'Driscoll, Caitriona M.
N1 - Publisher Copyright:
© 2017
PY - 2017/12
Y1 - 2017/12
N2 - Brain cancers are among the most lethal tumors due to their rapid development and poor prognosis. Despite the existing potential of novel therapeutic strategies for the treatment of brain cancer, the major remaining challenge associated with clinical translation is the lack of effective and safe delivery strategies to ensure drug transport to tumor tissues following systemic administration. Folate receptors, known to overexpress on different types of cancer cells, have been used to develop targeted delivery of therapeutic agents for cancer therapy. In this review, the potential of exploiting the folate receptor to achieve targeted cell-specific delivery of nanoparticles containing brain cancer therapeutics will be discussed in tandem with an analysis of the possible reasons for the current lack of clinical translation.
AB - Brain cancers are among the most lethal tumors due to their rapid development and poor prognosis. Despite the existing potential of novel therapeutic strategies for the treatment of brain cancer, the major remaining challenge associated with clinical translation is the lack of effective and safe delivery strategies to ensure drug transport to tumor tissues following systemic administration. Folate receptors, known to overexpress on different types of cancer cells, have been used to develop targeted delivery of therapeutic agents for cancer therapy. In this review, the potential of exploiting the folate receptor to achieve targeted cell-specific delivery of nanoparticles containing brain cancer therapeutics will be discussed in tandem with an analysis of the possible reasons for the current lack of clinical translation.
KW - blood-brain tumor barrier
KW - clinical translation
KW - CNS delivery
KW - nanoparticulate delivery vectors
UR - https://www.scopus.com/pages/publications/85029501350
U2 - 10.1016/j.xphs.2017.08.009
DO - 10.1016/j.xphs.2017.08.009
M3 - Short survey
C2 - 28842300
AN - SCOPUS:85029501350
SN - 0022-3549
VL - 106
SP - 3413
EP - 3420
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 12
ER -
