TY - JOUR
T1 - The Acid Tolerance Response of Salmonella spp.
T2 - An adaptive strategy to survive in stressful environments prevailing in foods and the host
AU - Álvarez-Ordóñez, Avelino
AU - Prieto, Miguel
AU - Bernardo, Ana
AU - Hill, Colin
AU - López, Mercedes
PY - 2012/3
Y1 - 2012/3
N2 - One of the best studied Salmonella spp. adaptive responses is the Acid Tolerance Response (ATR), responsible for bacterial survival under extreme acid conditions, and well characterized for Salmonella enterica serovar Typhimurium. This review covers the numerous studies carried out in the last two decades describing the influence of different environmental parameters on the S. Typhimurium ATR, including the complex molecular mechanisms implicated and involvement of the ATR in virulence. The review also deals with the food safety implications of this adaptive response. Finally, the limited data available regarding the ATR of other Salmonella enterica serovars is also discussed.
AB - One of the best studied Salmonella spp. adaptive responses is the Acid Tolerance Response (ATR), responsible for bacterial survival under extreme acid conditions, and well characterized for Salmonella enterica serovar Typhimurium. This review covers the numerous studies carried out in the last two decades describing the influence of different environmental parameters on the S. Typhimurium ATR, including the complex molecular mechanisms implicated and involvement of the ATR in virulence. The review also deals with the food safety implications of this adaptive response. Finally, the limited data available regarding the ATR of other Salmonella enterica serovars is also discussed.
KW - Acid shock proteins
KW - ATR
KW - Food safety
KW - Membrane composition
KW - PH homeostasis
KW - Salmonella Typhimurium
KW - Virulence
UR - https://www.scopus.com/pages/publications/84857414248
U2 - 10.1016/j.foodres.2011.04.002
DO - 10.1016/j.foodres.2011.04.002
M3 - Article
AN - SCOPUS:84857414248
SN - 0963-9969
VL - 45
SP - 482
EP - 492
JO - Food Research International
JF - Food Research International
IS - 2
ER -