The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand

Christina M. McSweeney; Vera M. Foley; Gerard P. McGlacken

doi:10.1039/c4cc06895e

The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand

Christina M. McSweeney
, Vera M. Foley
, Gerard P. McGlacken

School of Chemistry

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

The asymmetric alkylation of ketones represents a fundamental transformation in organic chemistry. Chiral auxiliaries have been used almost exclusively for this transformation. Herein we describe a strategy for the generation of enantiomerically enriched α-alkylated ketones up to an er of 83 : 17, using a chiral ligand protocol.

Original language	English
Pages (from-to)	14817-14819
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	94
DOIs	https://doi.org/10.1039/c4cc06895e
Publication status	Published - 30 Oct 2014

Access to Document

10.1039/c4cc06895e

Cite this

@article{ac6336b990604bf18b50c283c03284c1,

title = "The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand",

abstract = "The asymmetric alkylation of ketones represents a fundamental transformation in organic chemistry. Chiral auxiliaries have been used almost exclusively for this transformation. Herein we describe a strategy for the generation of enantiomerically enriched α-alkylated ketones up to an er of 83 : 17, using a chiral ligand protocol.",

author = "McSweeney, \{Christina M.\} and Foley, \{Vera M.\} and McGlacken, \{Gerard P.\}",

year = "2014",

month = oct,

day = "30",

doi = "10.1039/c4cc06895e",

language = "English",

volume = "50",

pages = "14817--14819",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "94",

}

TY - JOUR

T1 - The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand

AU - McSweeney, Christina M.

AU - Foley, Vera M.

AU - McGlacken, Gerard P.

PY - 2014/10/30

Y1 - 2014/10/30

N2 - The asymmetric alkylation of ketones represents a fundamental transformation in organic chemistry. Chiral auxiliaries have been used almost exclusively for this transformation. Herein we describe a strategy for the generation of enantiomerically enriched α-alkylated ketones up to an er of 83 : 17, using a chiral ligand protocol.

AB - The asymmetric alkylation of ketones represents a fundamental transformation in organic chemistry. Chiral auxiliaries have been used almost exclusively for this transformation. Herein we describe a strategy for the generation of enantiomerically enriched α-alkylated ketones up to an er of 83 : 17, using a chiral ligand protocol.

UR - https://www.scopus.com/pages/publications/84908637092

U2 - 10.1039/c4cc06895e

DO - 10.1039/c4cc06895e

M3 - Article

C2 - 25318599

AN - SCOPUS:84908637092

SN - 1359-7345

VL - 50

SP - 14817

EP - 14819

JO - Chemical Communications

JF - Chemical Communications

IS - 94

ER -

The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand

Abstract

Access to Document

Other files and links

Fingerprint

Cite this