The bovine colostrum and milk metabolome at the onset of lactation as determined by 1H-NMR

Tom F. O'Callaghan; Michael O'Donovan; John Paul Murphy; Katie Sugrue; John T. Tobin; Aoife E. McNamara; Xiaofei Yin; Geetha Sundaramoorthy; Lorraine Brennan

doi:10.1016/j.idairyj.2020.104881

The bovine colostrum and milk metabolome at the onset of lactation as determined by ¹H-NMR

Tom F. O'Callaghan
, Michael O'Donovan
, John Paul Murphy
, Katie Sugrue
, John T. Tobin
, Aoife E. McNamara
, Xiaofei Yin
, Geetha Sundaramoorthy
, Lorraine Brennan

School of Food and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this study was to characterise the metabolome of bovine colostrum and milk in the initial days of lactation. Colostrum and milk samples were collected from 18 cows representing an even spread of 1st, 2nd and 3rd lactation (n = 6) over the first 6 days of lactation. Samples were subsequently analysed using ¹H-NMR. The metabolome of defatted colostrum and milk in the days immediately post parturition was demonstrated to be complex and changed significantly over time. The colostrum was rich in nutrients beneficial for growth and development of the new-born mammal with significantly higher levels of essential branched chain amino acids and choline and orotic acid that decreased in the subsequent days as milk composition evolved to that of regular milk. Multivariate analysis of metabolome profiles using PLS-DA was demonstrated to clearly distinguish between colostrum and subsequent milk samples.

Original language	English
Article number	104881
Journal	International Dairy Journal
Volume	113
DOIs	https://doi.org/10.1016/j.idairyj.2020.104881
Publication status	Published - Feb 2021

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10.1016/j.idairyj.2020.104881

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title = "The bovine colostrum and milk metabolome at the onset of lactation as determined by 1H-NMR",

abstract = "The purpose of this study was to characterise the metabolome of bovine colostrum and milk in the initial days of lactation. Colostrum and milk samples were collected from 18 cows representing an even spread of 1st, 2nd and 3rd lactation (n = 6) over the first 6 days of lactation. Samples were subsequently analysed using 1H-NMR. The metabolome of defatted colostrum and milk in the days immediately post parturition was demonstrated to be complex and changed significantly over time. The colostrum was rich in nutrients beneficial for growth and development of the new-born mammal with significantly higher levels of essential branched chain amino acids and choline and orotic acid that decreased in the subsequent days as milk composition evolved to that of regular milk. Multivariate analysis of metabolome profiles using PLS-DA was demonstrated to clearly distinguish between colostrum and subsequent milk samples.",

author = "O'Callaghan, \{Tom F.\} and Michael O'Donovan and Murphy, \{John Paul\} and Katie Sugrue and Tobin, \{John T.\} and McNamara, \{Aoife E.\} and Xiaofei Yin and Geetha Sundaramoorthy and Lorraine Brennan",

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doi = "10.1016/j.idairyj.2020.104881",

language = "English",

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T1 - The bovine colostrum and milk metabolome at the onset of lactation as determined by 1H-NMR

AU - O'Callaghan, Tom F.

AU - O'Donovan, Michael

AU - Murphy, John Paul

AU - Sugrue, Katie

AU - Tobin, John T.

AU - McNamara, Aoife E.

AU - Yin, Xiaofei

AU - Sundaramoorthy, Geetha

AU - Brennan, Lorraine

PY - 2021/2

Y1 - 2021/2

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AB - The purpose of this study was to characterise the metabolome of bovine colostrum and milk in the initial days of lactation. Colostrum and milk samples were collected from 18 cows representing an even spread of 1st, 2nd and 3rd lactation (n = 6) over the first 6 days of lactation. Samples were subsequently analysed using 1H-NMR. The metabolome of defatted colostrum and milk in the days immediately post parturition was demonstrated to be complex and changed significantly over time. The colostrum was rich in nutrients beneficial for growth and development of the new-born mammal with significantly higher levels of essential branched chain amino acids and choline and orotic acid that decreased in the subsequent days as milk composition evolved to that of regular milk. Multivariate analysis of metabolome profiles using PLS-DA was demonstrated to clearly distinguish between colostrum and subsequent milk samples.

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DO - 10.1016/j.idairyj.2020.104881

M3 - Article

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SN - 0958-6946

VL - 113

JO - International Dairy Journal

JF - International Dairy Journal

M1 - 104881

ER -

The bovine colostrum and milk metabolome at the onset of lactation as determined by ¹H-NMR

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