The copious capabilities of non-coding RNAs in cancer regulation, diagnosis and treatment

Aideen McCabe; Oza Zaheed; Magdalina Derlipanska; George Merrin; Kellie Dean

doi:10.1016/j.ctarc.2023.100768

The copious capabilities of non-coding RNAs in cancer regulation, diagnosis and treatment

Aideen McCabe
, Oza Zaheed
, Magdalina Derlipanska
, George Merrin
, Kellie Dean

Research output: Contribution to journal › Article › peer-review

Abstract

Globally, cancer is one of the leading causes of mortality, accounting for 10 million deaths per year. Non-coding RNAs (ncRNAs) play integral and diverse roles in cancer, possessing the ability to both promote oncogenesis and impede tumor formation. This review discusses the various roles of microRNAs, transfer RNA-derived small RNAs, long non-coding RNAs and lncRNA-derived microproteins in cancer progression and prevention. We highlight the diagnostic and therapeutic potential of these ncRNAs, with a particular focus on detection in liquid biopsies and targeting of ncRNAs with small inhibitory molecules. Ultimately, the biological functions of cancer-associated ncRNAs, as well as the development of ncRNA-based technologies, are compelling areas for further research, holding the possibility of revolutionizing cancer treatment and diagnosis.

Original language	English
Article number	100768
Journal	Cancer Treatment and Research Communications
Volume	37
DOIs	https://doi.org/10.1016/j.ctarc.2023.100768
Publication status	Published - Jan 2023

Keywords

Cancer
Liquid biopsy
Microprotein
Non-coding RNA
Therapeutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ctarc.2023.100768

Cite this

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title = "The copious capabilities of non-coding RNAs in cancer regulation, diagnosis and treatment",

abstract = "Globally, cancer is one of the leading causes of mortality, accounting for 10 million deaths per year. Non-coding RNAs (ncRNAs) play integral and diverse roles in cancer, possessing the ability to both promote oncogenesis and impede tumor formation. This review discusses the various roles of microRNAs, transfer RNA-derived small RNAs, long non-coding RNAs and lncRNA-derived microproteins in cancer progression and prevention. We highlight the diagnostic and therapeutic potential of these ncRNAs, with a particular focus on detection in liquid biopsies and targeting of ncRNAs with small inhibitory molecules. Ultimately, the biological functions of cancer-associated ncRNAs, as well as the development of ncRNA-based technologies, are compelling areas for further research, holding the possibility of revolutionizing cancer treatment and diagnosis.",

keywords = "Cancer, Liquid biopsy, Microprotein, Non-coding RNA, Therapeutics",

author = "Aideen McCabe and Oza Zaheed and Magdalina Derlipanska and George Merrin and Kellie Dean",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = jan,

doi = "10.1016/j.ctarc.2023.100768",

language = "English",

volume = "37",

journal = "Cancer Treatment and Research Communications",

issn = "2213-0896",

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TY - JOUR

T1 - The copious capabilities of non-coding RNAs in cancer regulation, diagnosis and treatment

AU - McCabe, Aideen

AU - Zaheed, Oza

AU - Derlipanska, Magdalina

AU - Merrin, George

AU - Dean, Kellie

PY - 2023/1

Y1 - 2023/1

N2 - Globally, cancer is one of the leading causes of mortality, accounting for 10 million deaths per year. Non-coding RNAs (ncRNAs) play integral and diverse roles in cancer, possessing the ability to both promote oncogenesis and impede tumor formation. This review discusses the various roles of microRNAs, transfer RNA-derived small RNAs, long non-coding RNAs and lncRNA-derived microproteins in cancer progression and prevention. We highlight the diagnostic and therapeutic potential of these ncRNAs, with a particular focus on detection in liquid biopsies and targeting of ncRNAs with small inhibitory molecules. Ultimately, the biological functions of cancer-associated ncRNAs, as well as the development of ncRNA-based technologies, are compelling areas for further research, holding the possibility of revolutionizing cancer treatment and diagnosis.

AB - Globally, cancer is one of the leading causes of mortality, accounting for 10 million deaths per year. Non-coding RNAs (ncRNAs) play integral and diverse roles in cancer, possessing the ability to both promote oncogenesis and impede tumor formation. This review discusses the various roles of microRNAs, transfer RNA-derived small RNAs, long non-coding RNAs and lncRNA-derived microproteins in cancer progression and prevention. We highlight the diagnostic and therapeutic potential of these ncRNAs, with a particular focus on detection in liquid biopsies and targeting of ncRNAs with small inhibitory molecules. Ultimately, the biological functions of cancer-associated ncRNAs, as well as the development of ncRNA-based technologies, are compelling areas for further research, holding the possibility of revolutionizing cancer treatment and diagnosis.

KW - Cancer

KW - Liquid biopsy

KW - Microprotein

KW - Non-coding RNA

KW - Therapeutics

UR - https://www.scopus.com/pages/publications/85174010037

U2 - 10.1016/j.ctarc.2023.100768

DO - 10.1016/j.ctarc.2023.100768

M3 - Article

C2 - 37852123

AN - SCOPUS:85174010037

SN - 2213-0896

VL - 37

JO - Cancer Treatment and Research Communications

JF - Cancer Treatment and Research Communications

M1 - 100768

ER -

The copious capabilities of non-coding RNAs in cancer regulation, diagnosis and treatment

Abstract

Keywords

UN SDGs

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University College Cork Researchers Publish New Study Findings on Cancer (The copious capabilities of non-coding RNAs in cancer regulation, diagnosis and treatment)

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The copious capabilities of non-coding RNAs in cancer regulation, diagnosis and treatment

Abstract

Keywords

UN SDGs

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University College Cork Researchers Publish New Study Findings on Cancer (The copious capabilities of non-coding RNAs in cancer regulation, diagnosis and treatment)

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