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The development of enantioselective rhodium-catalysed hydroboration of olefins

  • University College Dublin
  • GlaxoSmithKline

Research output: Contribution to journalReview articlepeer-review

Abstract

Rhodium-catalysed enantioselective hydroboration of olefins is a valuable synthetic transformation, typically employing a chiral catalyst and an achiral borane source. The pertinent chemo-, regio- and enantioselectivity issues of this reaction are discussed. However, the main emphasis of this review is on the evolution of catalytic asymmetric hydroboration. This has primarily relied upon the development and application of chiral bidentate P,P and P,N ligands which have exhibited varying degrees of success in this transformation.

Original languageEnglish
Pages (from-to)609-631
Number of pages23
JournalAdvanced Synthesis and Catalysis
Volume347
Issue number5
DOIs
Publication statusPublished - Apr 2005
Externally publishedYes

Keywords

  • Asymmetric catalysis
  • Hydroboration
  • Mechanistic studies
  • P,N chiral ligands
  • P,P chiral ligands
  • Rhodium

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