Abstract
Background: The present study investigates the effect of cyclosporine A (CsA) on renal haemodynamics and excretory functions. Methods: Sprague-Dawley rats received CsA for 21 days at (25 mg/kg/day) p.o. The renal cortical vasoconstriction to noradrenaline, phenylep-hrine, methoxamine and angiotensin II was done at the end of treatment period. Data, mean±SEM were analyzed by ANOVA with significance at p<0.05.Results: CsA treated rats showed significant reduction in body weight, fluid intake, creatinine clearance, glomerular filtration rate, fractional sodium and potassium excretion with an elevation in blood pressure and urinary protein excretion compared to control. The renal vasoconstriction due to adrenergic agonists and angiotensin II was blunted although significant only for noradrenaline and angio-tensin II in CsA treated group compared to control.Conclusion: These fndings suggest an attenuation of AT 1 or α 1-adrenoceptors response to angiotensin II and adrenergic stimuli possibly due to higher sympathetic and renin-angiotensin systems activity in CsA-induced renal failure model.
| Original language | English |
|---|---|
| Pages (from-to) | 1857-1867 |
| Number of pages | 11 |
| Journal | HealthMED |
| Volume | 5 |
| Issue number | 6 SUPPL. 1 |
| Publication status | Published - 2011 |
| Externally published | Yes |
Keywords
- α adrenoceptor
- Cyclosporine a
- Noradrenaline
- Renal failure
- Sprague-dawley rats
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