The FDG lumped constant in normal human brain

Michael M. Graham; Mark Muzi; Alexander M. Spence; Finbarr O'Sullivan; Thomas K. Lewellen; Jeanne M. Link; Kenneth A. Krohn

The FDG lumped constant in normal human brain

Michael M. Graham
, Mark Muzi
, Alexander M. Spence
, Finbarr O'Sullivan
, Thomas K. Lewellen
, Jeanne M. Link
, Kenneth A. Krohn

University of Iowa

Research output: Contribution to journal › Article › peer-review

Abstract

The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MR_glc) from FDG metabolic rate (MR_FDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MR_glc and MR_FDG independently using l-¹¹C-glucose and ¹⁸F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.

Original language	English
Pages (from-to)	1157-1166
Number of pages	10
Journal	Journal of Nuclear Medicine
Volume	43
Issue number	9
Publication status	Published - Sep 2002
Externally published	Yes

Keywords

C-glucose
FDG
Glucose metabolism
Lumped constant

Cite this

@article{90e1d91501514c8996fcefcde226cd43,

title = "The FDG lumped constant in normal human brain",

abstract = "The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc) from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MRglc and MRFDG independently using l-11C-glucose and 18F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.",

keywords = "C-glucose, FDG, Glucose metabolism, Lumped constant",

author = "Graham, \{Michael M.\} and Mark Muzi and Spence, \{Alexander M.\} and Finbarr O'Sullivan and Lewellen, \{Thomas K.\} and Link, \{Jeanne M.\} and Krohn, \{Kenneth A.\}",

year = "2002",

month = sep,

language = "English",

volume = "43",

pages = "1157--1166",

journal = "Journal of Nuclear Medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine Inc.",

number = "9",

}

TY - JOUR

T1 - The FDG lumped constant in normal human brain

AU - Graham, Michael M.

AU - Muzi, Mark

AU - Spence, Alexander M.

AU - O'Sullivan, Finbarr

AU - Lewellen, Thomas K.

AU - Link, Jeanne M.

AU - Krohn, Kenneth A.

PY - 2002/9

Y1 - 2002/9

N2 - The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc) from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MRglc and MRFDG independently using l-11C-glucose and 18F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.

AB - The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc) from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MRglc and MRFDG independently using l-11C-glucose and 18F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.

KW - C-glucose

KW - FDG

KW - Glucose metabolism

KW - Lumped constant

UR - https://www.scopus.com/pages/publications/0036733752

M3 - Article

C2 - 12215553

AN - SCOPUS:0036733752

SN - 0161-5505

VL - 43

SP - 1157

EP - 1166

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 9

ER -

The FDG lumped constant in normal human brain

Abstract

Keywords

Other files and links

Fingerprint

Cite this