The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific

Andrey N. Shkoporov; Adam G. Clooney; Thomas D.S. Sutton; Feargal J. Ryan; Karen M. Daly; James A. Nolan; Siobhan A. McDonnell; Ekaterina V. Khokhlova; Lorraine A. Draper; Amanda Forde; Emma Guerin; Vimalkumar Velayudhan; R. Paul Ross; Colin Hill

doi:10.1016/j.chom.2019.09.009

The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific

Andrey N. Shkoporov
, Adam G. Clooney
, Thomas D.S. Sutton
, Feargal J. Ryan
, Karen M. Daly
, James A. Nolan
, Siobhan A. McDonnell
, Ekaterina V. Khokhlova
, Lorraine A. Draper
, Amanda Forde
, Emma Guerin
, Vimalkumar Velayudhan
, R. Paul Ross
, Colin Hill

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

Shkoporov et al. demonstrate high individual specificity and temporal stability of the human gut virome. They describe a numerically prevalent and persisting fraction of the viral community, termed persistent personal virome (PPV). The PPV consists mainly of virulent bacteriophages predicted to target major taxonomic groups of gut bacteria.

Original language	English
Pages (from-to)	527-541.e5
Journal	Cell Host and Microbe
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2019.09.009
Publication status	Published - 9 Oct 2019

Keywords

bacteriophages
crAss-like phages
crAssphage
CRISPR
human microbiome
longitudinal study
Microviridae
persistent personal virome
phageome
virome

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10.1016/j.chom.2019.09.009

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Shkoporov, A. N., Clooney, A. G., Sutton, T. D. S., Ryan, F. J., Daly, K. M., Nolan, J. A., McDonnell, S. A., Khokhlova, E. V., Draper, L. A., Forde, A., Guerin, E., Velayudhan, V., Ross, R. P., & Hill, C. (2019). The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific. Cell Host and Microbe, 26(4), 527-541.e5. https://doi.org/10.1016/j.chom.2019.09.009

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abstract = "Shkoporov et al. demonstrate high individual specificity and temporal stability of the human gut virome. They describe a numerically prevalent and persisting fraction of the viral community, termed persistent personal virome (PPV). The PPV consists mainly of virulent bacteriophages predicted to target major taxonomic groups of gut bacteria.",

keywords = "bacteriophages, crAss-like phages, crAssphage, CRISPR, human microbiome, longitudinal study, Microviridae, persistent personal virome, phageome, virome",

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AU - Shkoporov, Andrey N.

AU - Clooney, Adam G.

AU - Sutton, Thomas D.S.

AU - Ryan, Feargal J.

AU - Daly, Karen M.

AU - Nolan, James A.

AU - McDonnell, Siobhan A.

AU - Khokhlova, Ekaterina V.

AU - Draper, Lorraine A.

AU - Forde, Amanda

AU - Guerin, Emma

AU - Velayudhan, Vimalkumar

AU - Ross, R. Paul

AU - Hill, Colin

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AB - Shkoporov et al. demonstrate high individual specificity and temporal stability of the human gut virome. They describe a numerically prevalent and persisting fraction of the viral community, termed persistent personal virome (PPV). The PPV consists mainly of virulent bacteriophages predicted to target major taxonomic groups of gut bacteria.

KW - bacteriophages

KW - crAss-like phages

KW - crAssphage

KW - CRISPR

KW - human microbiome

KW - longitudinal study

KW - Microviridae

KW - persistent personal virome

KW - phageome

KW - virome

UR - https://www.scopus.com/pages/publications/85072511956

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DO - 10.1016/j.chom.2019.09.009

M3 - Article

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AN - SCOPUS:85072511956

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VL - 26

SP - 527-541.e5

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 4

ER -

The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific

Abstract

Keywords

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