The lactococcal phages Tuc2009 and TP901-1 incorporate two alternate forms of their tail fiber into their virions for infection specialization

  • Stephen R. Stockdale
  • , Jennifer Mahony
  • , Pascal Courtin
  • , Marie Pierre Chapot-Chartier
  • , Jan Peter Van Pijkeren
  • , Robert A. Britton
  • , Horst Neve
  • , Knut J. Heller
  • , Bashir Aideh
  • , Finn K. Vogensen
  • , Douwe Van Sinderen

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Siphoviridae virions often possess lytic domains facilitating host-penetration. Results: Tuc2009 and TP901-1 virions may contain full-length or truncated tail fibers, possessing or lacking a lytic domain, respectively. Conclusion: Phages with a lytic domain infect stationary phase cells better, whereas truncated derivatives have higher adsorption efficiencies. Significance: The heterogeneous phage population serves to most effectively infect bacteria where levels of cell wall crosslinkage differ.

Original languageEnglish
Pages (from-to)5581-5590
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number8
DOIs
Publication statusPublished - 22 Feb 2013

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