The role of PAT in the development of telescoped continuous flow processes

Aoife M. Kearney; Stuart G. Collins; Anita R. Maguire

doi:10.1039/d3re00678f

The role of PAT in the development of telescoped continuous flow processes

Aoife M. Kearney
, Stuart G. Collins
, Anita R. Maguire

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

This review highlights the advantages of incorporating Process Analytical Technologies into continuous flow processes, especially in the context of telescoped multistep flow sequences. Use of FlowIR, in-line UV-vis, online HPLC, online MS and Flow NMR are discussed within this review, with multiple PAT techniques used in conjunction with one another in some instances. PAT is key in ensuring as much information as possible can be gathered during a chemical transformation, with real-time analysis allowing for rapid reaction optimization.

Original language	English
Pages (from-to)	990-1013
Number of pages	24
Journal	Reaction Chemistry and Engineering
Volume	9
Issue number	5
DOIs	https://doi.org/10.1039/d3re00678f
Publication status	Published - 14 Mar 2024

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10.1039/d3re00678f

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title = "The role of PAT in the development of telescoped continuous flow processes",

abstract = "This review highlights the advantages of incorporating Process Analytical Technologies into continuous flow processes, especially in the context of telescoped multistep flow sequences. Use of FlowIR, in-line UV-vis, online HPLC, online MS and Flow NMR are discussed within this review, with multiple PAT techniques used in conjunction with one another in some instances. PAT is key in ensuring as much information as possible can be gathered during a chemical transformation, with real-time analysis allowing for rapid reaction optimization.",

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The role of PAT in the development of telescoped continuous flow processes

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Findings from University College Cork Update Knowledge of Reaction Chemistry and Engineering (The Role of Pat In the Development of Telescoped Continuous Flow Processes)

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The role of PAT in the development of telescoped continuous flow processes

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Findings from University College Cork Update Knowledge of Reaction Chemistry and Engineering (The Role of Pat In the Development of Telescoped Continuous Flow Processes)

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