Abstract
Unmet clinical diagnostic needs exist for many complex diseases, which (it is hoped) will be solved by the discovery of metabolomics biomarkers. However, at present, no diagnostic tests based on metabolomics have yet been introduced to the clinic. This review is presented as a research perspective on how data analysis methods in metabolomics biomarker discovery may contribute to the failure of biomarker studies and suggests how such failures might be mitigated. The study design and data pretreatment steps are reviewed briefly in this context, and the actual data analysis step is examined more closely.
| Original language | English |
|---|---|
| Article number | 126 |
| Journal | Metabolites |
| Volume | 9 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2019 |
Keywords
- Biomarker discovery
- Complex disease
- Data analysis
- Heterogeneous disease
- Metabolomics
- Modeling
- Precision medicine
- Reproducibility