The spiFEG locus in Streptococcus infantarius subsp. infantarius BAA-102 confers protection against nisin U

Lorraine A. Draper; John R. Tagg; Colin Hill; Paul D. Cotter; R. Paul Ross

doi:10.1128/AAC.05778-11

The spiFEG locus in Streptococcus infantarius subsp. infantarius BAA-102 confers protection against nisin U

Lorraine A. Draper
, John R. Tagg
, Colin Hill
, Paul D. Cotter
, R. Paul Ross

Research output: Contribution to journal › Article › peer-review

Abstract

Nisin U is a member of the extended nisin family of lantibiotics. Here we identify the presence of nisin U immunity gene homologues in Streptococcus infantarius subsp. infantarius BAA-102. Heterologous expression of these genes in Lactococcus lactis subsp. cremoris HP confers protection to nisin U and other members of the nisin family, thereby establishing that the recently identified phenomenon of resistance through immune mimicry also occurs with respect to nisin.

Original language	English
Pages (from-to)	573-578
Number of pages	6
Journal	Antimicrobial Agents and Chemotherapy
Volume	56
Issue number	1
DOIs	https://doi.org/10.1128/AAC.05778-11
Publication status	Published - Jan 2012

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abstract = "Nisin U is a member of the extended nisin family of lantibiotics. Here we identify the presence of nisin U immunity gene homologues in Streptococcus infantarius subsp. infantarius BAA-102. Heterologous expression of these genes in Lactococcus lactis subsp. cremoris HP confers protection to nisin U and other members of the nisin family, thereby establishing that the recently identified phenomenon of resistance through immune mimicry also occurs with respect to nisin.",

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AU - Cotter, Paul D.

AU - Ross, R. Paul

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AB - Nisin U is a member of the extended nisin family of lantibiotics. Here we identify the presence of nisin U immunity gene homologues in Streptococcus infantarius subsp. infantarius BAA-102. Heterologous expression of these genes in Lactococcus lactis subsp. cremoris HP confers protection to nisin U and other members of the nisin family, thereby establishing that the recently identified phenomenon of resistance through immune mimicry also occurs with respect to nisin.

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The spiFEG locus in Streptococcus infantarius subsp. infantarius BAA-102 confers protection against nisin U

Abstract

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